Interhemispheric motor networks are abnormal in patients with Gilles de la Tourette syndrome
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Interhemispheric motor networks are abnormal in patients with Gilles de la Tourette syndrome. / Bäumer, Tobias; Thomalla, Götz; Kroeger, Johan; Jonas, Melanie; Gerloff, Christian; Hummel, Friedhelm Christoph; Müller-Vahl, Kirsten; Schnitzler, Alfons; Siebner, Hartwig Roman; Orth, Michael; Münchau, Alexander.
I: Movement Disorders, Bind 25, Nr. 16, 15.12.2010, s. 2828-37.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Interhemispheric motor networks are abnormal in patients with Gilles de la Tourette syndrome
AU - Bäumer, Tobias
AU - Thomalla, Götz
AU - Kroeger, Johan
AU - Jonas, Melanie
AU - Gerloff, Christian
AU - Hummel, Friedhelm Christoph
AU - Müller-Vahl, Kirsten
AU - Schnitzler, Alfons
AU - Siebner, Hartwig Roman
AU - Orth, Michael
AU - Münchau, Alexander
N1 - © 2010 Movement Disorder Society.
PY - 2010/12/15
Y1 - 2010/12/15
N2 - Brain imaging has shown altered corpus callosum (CC) morphology in patients with Gilles de la Tourette syndrome (GTS). Yet it is unclear whether these morphological changes are associated with altered interhemispheric interactions. Here, we combined transcranial magnetic stimulation (TMS) with diffusion tensor magnetic resonance imaging (DTI) to explore functional and structural interhemispheric connections between the left and right motor hand areas. We studied 14 unmedicated GTS patients without psychiatric comorbidity (2 women, mean age 35.5 years) and 15 healthy volunteers (3 women, mean age 35 years). Left-to-right and right-to-left interhemispheric inhibitions (IHIs) were measured in hand muscles with TMS. In 13 GTS patients and all healthy controls, we measured fractional anisotropy (FA) with DTI to examine the relation between functional measures of interhemispheric connectivity as derived by TMS and structural properties of the CC region that carries fibers interconnecting both motor cortices. In GTS patients, left-to-right IHI was weaker than right-to-left IHI. Left-to-right IHI in GTS patients was also reduced compared with healthy controls. Voxel-based morphometric analysis revealed that FA in the motor region of the CC did not differ between groups. However, there was a significant interaction between groups and the relation between regional FA and left-to-right IHI in the motor region of the CC. A negative linear relation between FA and left-to-right IHI was present in control subjects but not in patients. Our combined TMS-DTI approach demonstrates abnormal functional interhemispheric connectivity in GTS accompanied by an altered structure-function relationship in the motor CC.
AB - Brain imaging has shown altered corpus callosum (CC) morphology in patients with Gilles de la Tourette syndrome (GTS). Yet it is unclear whether these morphological changes are associated with altered interhemispheric interactions. Here, we combined transcranial magnetic stimulation (TMS) with diffusion tensor magnetic resonance imaging (DTI) to explore functional and structural interhemispheric connections between the left and right motor hand areas. We studied 14 unmedicated GTS patients without psychiatric comorbidity (2 women, mean age 35.5 years) and 15 healthy volunteers (3 women, mean age 35 years). Left-to-right and right-to-left interhemispheric inhibitions (IHIs) were measured in hand muscles with TMS. In 13 GTS patients and all healthy controls, we measured fractional anisotropy (FA) with DTI to examine the relation between functional measures of interhemispheric connectivity as derived by TMS and structural properties of the CC region that carries fibers interconnecting both motor cortices. In GTS patients, left-to-right IHI was weaker than right-to-left IHI. Left-to-right IHI in GTS patients was also reduced compared with healthy controls. Voxel-based morphometric analysis revealed that FA in the motor region of the CC did not differ between groups. However, there was a significant interaction between groups and the relation between regional FA and left-to-right IHI in the motor region of the CC. A negative linear relation between FA and left-to-right IHI was present in control subjects but not in patients. Our combined TMS-DTI approach demonstrates abnormal functional interhemispheric connectivity in GTS accompanied by an altered structure-function relationship in the motor CC.
KW - Adult
KW - Anisotropy
KW - Brain Mapping
KW - Corpus Callosum
KW - Diffusion Magnetic Resonance Imaging
KW - Female
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Male
KW - Middle Aged
KW - Motor Cortex
KW - Nerve Net
KW - Severity of Illness Index
KW - Tourette Syndrome
KW - Transcranial Magnetic Stimulation
U2 - 10.1002/mds.23418
DO - 10.1002/mds.23418
M3 - Journal article
C2 - 20960481
VL - 25
SP - 2828
EP - 2837
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 16
ER -
ID: 33437710