Intercellular communication between artificial cells by allosteric amplification of a molecular signal
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Intercellular communication between artificial cells by allosteric amplification of a molecular signal. / Buddingh’, Bastiaan C.; Elzinga, Janneke; Hest, Jan C. M. van.
I: Nature Communications, Bind 11, 1652, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Intercellular communication between artificial cells by allosteric amplification of a molecular signal
AU - Buddingh’, Bastiaan C.
AU - Elzinga, Janneke
AU - Hest, Jan C. M. van
PY - 2020
Y1 - 2020
N2 - Multicellular organisms rely on intercellular communication to coordinate the behaviour of individual cells, which enables their differentiation and hierarchical organization. Various cell mimics have been developed to establish fundamental engineering principles for the construction of artificial cells displaying cell-like organization, behaviour and complexity. However, collective phenomena, although of great importance for a better understanding of life-like behaviour, are underexplored. Here, we construct collectives of giant vesicles that can communicate with each other through diffusing chemical signals that are recognized and processed by synthetic enzymatic cascades. Similar to biological cells, the Receiver vesicles can transduce a weak signal originating from Sender vesicles into a strong response by virtue of a signal amplification step, which facilitates the propagation of signals over long distances within the artificial cell consortia. This design advances the development of interconnected artificial cells that can exchange metabolic and positional information to coordinate their higher-order organization.
AB - Multicellular organisms rely on intercellular communication to coordinate the behaviour of individual cells, which enables their differentiation and hierarchical organization. Various cell mimics have been developed to establish fundamental engineering principles for the construction of artificial cells displaying cell-like organization, behaviour and complexity. However, collective phenomena, although of great importance for a better understanding of life-like behaviour, are underexplored. Here, we construct collectives of giant vesicles that can communicate with each other through diffusing chemical signals that are recognized and processed by synthetic enzymatic cascades. Similar to biological cells, the Receiver vesicles can transduce a weak signal originating from Sender vesicles into a strong response by virtue of a signal amplification step, which facilitates the propagation of signals over long distances within the artificial cell consortia. This design advances the development of interconnected artificial cells that can exchange metabolic and positional information to coordinate their higher-order organization.
U2 - 10.1038/s41467-020-15482-8
DO - 10.1038/s41467-020-15482-8
M3 - Journal article
VL - 11
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 1652
ER -
ID: 359858533