Insulin pump therapy in children with type 1 diabetes: analysis of data from the SWEET registry
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Insulin pump therapy in children with type 1 diabetes : analysis of data from the SWEET registry. / Szypowska, Agnieszka; Schwandt, Anke; Svensson, Jannet; Shalitin, Shlomit; Cardona-Hernandez, Roque; Forsander, Gun; Sundberg, Frida; de Beaufort, Carine; Maahs, David M; Maffeis, Claudio; O'Riordan, Stephen M P; Krisane, Iveta Dzivite; Scharf, Mauro; Castro, Sofia; Konstantinova, Maia; Obermannova, Barbora; Casteels, Kristina; Gökşen, Damla; Galhardo, Júlia; Kanaka-Gantenbein, Christina; Rami-Merhar, Birgit; Madacsy, Laszlo; SWEET Study Group.
I: Pediatric Diabetes, Bind 17, Nr. S23, 10.2016, s. 38-45.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Insulin pump therapy in children with type 1 diabetes
T2 - analysis of data from the SWEET registry
AU - Szypowska, Agnieszka
AU - Schwandt, Anke
AU - Svensson, Jannet
AU - Shalitin, Shlomit
AU - Cardona-Hernandez, Roque
AU - Forsander, Gun
AU - Sundberg, Frida
AU - de Beaufort, Carine
AU - Maahs, David M
AU - Maffeis, Claudio
AU - O'Riordan, Stephen M P
AU - Krisane, Iveta Dzivite
AU - Scharf, Mauro
AU - Castro, Sofia
AU - Konstantinova, Maia
AU - Obermannova, Barbora
AU - Casteels, Kristina
AU - Gökşen, Damla
AU - Galhardo, Júlia
AU - Kanaka-Gantenbein, Christina
AU - Rami-Merhar, Birgit
AU - Madacsy, Laszlo
AU - SWEET Study Group
N1 - © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2016/10
Y1 - 2016/10
N2 - BACKGROUND: Intensified insulin delivery using multiple daily injections (MDI) or continuous subcutaneous insulin infusion (CSII) is recommended in children with type 1 diabetes (T1D) to achieve good metabolic control.OBJECTIVE: To examine the frequency of pump usage in T1D children treated in SWEET (Better control in Paediatric and Adolescent diabeteS: Working to crEate CEnTers of Reference) centers and to compare metabolic control between patients treated with CSII vs MDI.METHODS: This study included 16 570 T1D children participating in the SWEET prospective, multicenter, standardized diabetes patient registry. Datasets were aggregated over the most recent year of treatment for each patient. Data were collected until March 2016. To assess the organization of pump therapy a survey was carried out.RESULTS: Overall, 44.4% of T1D children were treated with CSII. The proportion of patients with pump usage varied between centers and decreased with increasing age compared with children treated with MDI. In a logistic regression analysis adjusting for age, gender and diabetes duration, the use of pump was associated with both: center size [odd ratio 1.51 (1.47-1.55), P < .0001) and the diabetes-related expenditure per capita [odd ratio 1.55 (1.49-1.61), P < .0001]. Linear regression analysis, adjusted for age, gender, and diabetes duration showed that both HbA1c and daily insulin dose (U/kg/d) remained decreased in children treated with CSII compared to MDI (P < .0001).CONCLUSIONS: Insulin pump therapy is offered by most Sweet centers. The differences between centers affect the frequency of use of modern technology. Despite the heterogeneity of centers, T1D children achieve relatively good metabolic control, especially those treated with insulin pumps and those of younger age.
AB - BACKGROUND: Intensified insulin delivery using multiple daily injections (MDI) or continuous subcutaneous insulin infusion (CSII) is recommended in children with type 1 diabetes (T1D) to achieve good metabolic control.OBJECTIVE: To examine the frequency of pump usage in T1D children treated in SWEET (Better control in Paediatric and Adolescent diabeteS: Working to crEate CEnTers of Reference) centers and to compare metabolic control between patients treated with CSII vs MDI.METHODS: This study included 16 570 T1D children participating in the SWEET prospective, multicenter, standardized diabetes patient registry. Datasets were aggregated over the most recent year of treatment for each patient. Data were collected until March 2016. To assess the organization of pump therapy a survey was carried out.RESULTS: Overall, 44.4% of T1D children were treated with CSII. The proportion of patients with pump usage varied between centers and decreased with increasing age compared with children treated with MDI. In a logistic regression analysis adjusting for age, gender and diabetes duration, the use of pump was associated with both: center size [odd ratio 1.51 (1.47-1.55), P < .0001) and the diabetes-related expenditure per capita [odd ratio 1.55 (1.49-1.61), P < .0001]. Linear regression analysis, adjusted for age, gender, and diabetes duration showed that both HbA1c and daily insulin dose (U/kg/d) remained decreased in children treated with CSII compared to MDI (P < .0001).CONCLUSIONS: Insulin pump therapy is offered by most Sweet centers. The differences between centers affect the frequency of use of modern technology. Despite the heterogeneity of centers, T1D children achieve relatively good metabolic control, especially those treated with insulin pumps and those of younger age.
KW - Adolescent
KW - Blood Glucose
KW - Child
KW - Child, Preschool
KW - Diabetes Mellitus, Type 1
KW - Female
KW - Humans
KW - Infant
KW - Injections
KW - Insulin Infusion Systems
KW - Male
KW - Registries
KW - Comparative Study
KW - Journal Article
KW - Multicenter Study
KW - Research Support, Non-U.S. Gov't
U2 - 10.1111/pedi.12416
DO - 10.1111/pedi.12416
M3 - Journal article
C2 - 27417128
VL - 17
SP - 38
EP - 45
JO - Pediatric Diabetes
JF - Pediatric Diabetes
SN - 1399-543X
IS - S23
ER -
ID: 179312812