Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation
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Recently, evidence has emerged that small-conductance Ca(2+)-activated K(+) (SK) channels are predominantly expressed in the atria in a number of species including human. In rat, guinea pig, and rabbit ex vivo and in vivo models of atrial fibrillation (AF), we used 3 different SK channel inhibitors, UCL1684, N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (ICA), and NS8593, to assess the hypothesis that pharmacological inhibition of SK channels is antiarrhythmic.
Originalsprog | Engelsk |
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Tidsskrift | Circulation. Arrhythmia and electrophysiology |
Vol/bind | 3 |
Udgave nummer | 4 |
Sider (fra-til) | 380-90 |
Antal sider | 11 |
DOI | |
Status | Udgivet - aug. 2010 |
ID: 33016849