Influence of female bodyweight on IVF outcome: a longitudinal multicentre cohort study of 487 infertile couples
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Influence of female bodyweight on IVF outcome: a longitudinal multicentre cohort study of 487 infertile couples. / Pinborg, A; Gaarslev, C; Hougaard, C O; Andersen, Anders Nyboe; Andersen, P K; Boivin, J; Schmidt, L.
I: Reproductive BioMedicine Online, Bind 23, Nr. 4, 2011, s. 490-499.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Influence of female bodyweight on IVF outcome: a longitudinal multicentre cohort study of 487 infertile couples
AU - Pinborg, A
AU - Gaarslev, C
AU - Hougaard, C O
AU - Andersen, Anders Nyboe
AU - Andersen, P K
AU - Boivin, J
AU - Schmidt, L
N1 - Copyright © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
PY - 2011
Y1 - 2011
N2 - This study investigated the impact of women's body mass index (BMI) on the outcome after consecutive IVF/intracytoplasmic sperm injection cycles in 487 patients initiating treatment with 5-year follow-up. The total number of cycles was 1417. In total 103 (21.1%) were overweight (BMI 25-29.9 kg/m²) and 59 (12.1%) were obese (BMI ≥ 30 kg/m²). Number of initiated cycles/woman (P=0.01), number of cancelled cycles/woman (P <0.01) and the total dose of gonadotrophin used/cycle (P <0.01) rose with increasing BMI. A negative linear association between BMI and the number of retrieved oocytes (B=-0.243, P <0.001) and an inverse U-shaped relationship between BMI and the number of developed embryos was seen, with less embryos available among underweight and obese women (P=0.03). The number with positive serum human chorionic gonadotrophin/cycle decreased significantly with increasing BMI (P <0.01). The ongoing pregnancy rate/cycle among the obese women was lower (20.8% versus 28.3% in normal-weight women; P=0.04). Live-birth rate per cycle was 15.2% versus 21.5%. Multiple logistic regression analysis showed that the only independent predictors of live birth were women's age (P=0.037), women's BMI (P=0.034) and men's age (P=0.040).
AB - This study investigated the impact of women's body mass index (BMI) on the outcome after consecutive IVF/intracytoplasmic sperm injection cycles in 487 patients initiating treatment with 5-year follow-up. The total number of cycles was 1417. In total 103 (21.1%) were overweight (BMI 25-29.9 kg/m²) and 59 (12.1%) were obese (BMI ≥ 30 kg/m²). Number of initiated cycles/woman (P=0.01), number of cancelled cycles/woman (P <0.01) and the total dose of gonadotrophin used/cycle (P <0.01) rose with increasing BMI. A negative linear association between BMI and the number of retrieved oocytes (B=-0.243, P <0.001) and an inverse U-shaped relationship between BMI and the number of developed embryos was seen, with less embryos available among underweight and obese women (P=0.03). The number with positive serum human chorionic gonadotrophin/cycle decreased significantly with increasing BMI (P <0.01). The ongoing pregnancy rate/cycle among the obese women was lower (20.8% versus 28.3% in normal-weight women; P=0.04). Live-birth rate per cycle was 15.2% versus 21.5%. Multiple logistic regression analysis showed that the only independent predictors of live birth were women's age (P=0.037), women's BMI (P=0.034) and men's age (P=0.040).
U2 - 10.1016/j.rbmo.2011.06.010
DO - 10.1016/j.rbmo.2011.06.010
M3 - Journal article
C2 - 21856228
VL - 23
SP - 490
EP - 499
JO - Reproductive BioMedicine Online
JF - Reproductive BioMedicine Online
SN - 1472-6483
IS - 4
ER -
ID: 34082087