Inflammatory markers in relation to maternal lifestyle and adverse pregnancy outcomes in twin pregnancies
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It is well known that inflammatory markers play an important role in the development and maintenance of healthy pregnancies. However, the literature regarding inflammation in relation to lifestyle and adverse pregnancy outcomes in twin pregnancies is remarkably uncovered. Therefore, this study aimed at evaluating the concentration of inflammatory markers in dried capillary blood spot samples from 523 women with twin pregnancies, included at a median gestational age of 21+1 weeks. The relationship between inflammatory markers and maternal lifestyle (current smoking status and pre-pregnancy body mass index) in addition to adverse pregnancy outcomes (preeclampsia, gestational diabetes mellitus, and small for gestational age) was analyzed. The study showed that active smoking at inclusion was associated with an elevated concentration of interleukin-8. Furthermore, maternal obesity was associated with an elevated concentration of C-reactive protein and monocyte chemoattractant protein-1. Analysis of the data showed no statistically significant variations in the concentration of the assessed inflammatory markers for neither preeclampsia, gestational diabetes mellitus, nor small for gestational age. The current study promotes future research on the pathophysiology of twin pregnancies in relation to adverse pregnancy outcomes, as the literature within the area remains scarce.
Originalsprog | Engelsk |
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Artikelnummer | 104286 |
Tidsskrift | Journal of Reproductive Immunology |
Vol/bind | 164 |
Antal sider | 7 |
ISSN | 0165-0378 |
DOI | |
Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:
Funding for the Prevention of Preterm Delivery in Twin Gestations (PREDICT) study was provided by The Danish Medical Research Council, The Fetal Medicine Foundation, The Copenhagen University Hospital's Research Fund, The Aase and Ejnar Danielsens Fund, The Augustinus Fund, The Ivan Nielsen Fund, The Doctor Sofus Carl Emil Friis and wife Olga Doris Friis\u2019 Fund, The Simon Fougner Hartmanns Family Fund, The Danish Medical Society in Copenhagen, and The A. P. Moeller Foundation.
Publisher Copyright:
© 2024 Elsevier B.V.
ID: 397717096