Inflammatory and oxidative stress biomarkers in children and adolescents with bipolar disorder – A systematic review and meta-analysis
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Inflammatory and oxidative stress biomarkers in children and adolescents with bipolar disorder – A systematic review and meta-analysis. / Munkholm, Klaus; Mäkinen, Ilari Jaakko Olavi; Maigaard, Katrine; Coello, Klara; Pagsberg, Anne Katrine; Kessing, Lars Vedel.
I: Neuroscience and Biobehavioral Reviews, Bind 163, 105766, 2024.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Inflammatory and oxidative stress biomarkers in children and adolescents with bipolar disorder – A systematic review and meta-analysis
AU - Munkholm, Klaus
AU - Mäkinen, Ilari Jaakko Olavi
AU - Maigaard, Katrine
AU - Coello, Klara
AU - Pagsberg, Anne Katrine
AU - Kessing, Lars Vedel
N1 - Publisher Copyright: © 2024 Elsevier Ltd
PY - 2024
Y1 - 2024
N2 - Evidence suggests a role for low-grade inflammation and oxidative stress in the pathophysiology of bipolar disorder. We conducted a systematic review and meta-analysis of peripheral markers of inflammation and oxidative stress in children and adolescents under 20 years of age with bipolar disorder. We searched PubMed, Embase and psycINFO and performed random effects meta-analysis calculating standardized mean differences (SMD) of marker levels between patients with bipolar disorder and healthy control individuals. Ten studies comprising a total of 418 patients with bipolar disorder and 3017 healthy control individuals were included. The levels of C-Reactive Protein were higher in patients with bipolar disorder compared with healthy individuals (SMD 0.53; 95 %CI: 0.33–0.74; I2 = 0 %). For other biomarkers there were no statistically significant differences between groups. Findings were limited by a low number of studies and participants and methodological issues in the included studies. More and larger studies using rigorous methodology are needed to establish the role of inflammation and oxidative stress in children and adolescents with bipolar disorder.
AB - Evidence suggests a role for low-grade inflammation and oxidative stress in the pathophysiology of bipolar disorder. We conducted a systematic review and meta-analysis of peripheral markers of inflammation and oxidative stress in children and adolescents under 20 years of age with bipolar disorder. We searched PubMed, Embase and psycINFO and performed random effects meta-analysis calculating standardized mean differences (SMD) of marker levels between patients with bipolar disorder and healthy control individuals. Ten studies comprising a total of 418 patients with bipolar disorder and 3017 healthy control individuals were included. The levels of C-Reactive Protein were higher in patients with bipolar disorder compared with healthy individuals (SMD 0.53; 95 %CI: 0.33–0.74; I2 = 0 %). For other biomarkers there were no statistically significant differences between groups. Findings were limited by a low number of studies and participants and methodological issues in the included studies. More and larger studies using rigorous methodology are needed to establish the role of inflammation and oxidative stress in children and adolescents with bipolar disorder.
KW - Adolescents
KW - Bipolar disorder
KW - Children
KW - Inflammation
KW - Meta-analysis
KW - Oxidative stress
U2 - 10.1016/j.neubiorev.2024.105766
DO - 10.1016/j.neubiorev.2024.105766
M3 - Review
C2 - 38885887
AN - SCOPUS:85196263269
VL - 163
JO - Neuroscience & Biobehavioral Reviews
JF - Neuroscience & Biobehavioral Reviews
SN - 0149-7634
M1 - 105766
ER -
ID: 395825915