Inflammation og frie oxygenradikaler
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Inflammation og frie oxygenradikaler. / Nielsen, O H; Ahnfelt-Rønne, I.
I: Nordisk Medicin, Bind 104, Nr. 8-9, 1989, s. 216-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Inflammation og frie oxygenradikaler
AU - Nielsen, O H
AU - Ahnfelt-Rønne, I
PY - 1989
Y1 - 1989
N2 - When mammalian phagocytes encounter appropriate stimuli, highly reactive oxygen derived free radicals (superoxide and hydroxyl) and related species (hydrogen peroxide and hypochlorous acid) may be produced as a normal mechanism in the defence of the host against invading microorganisms. The radicals are destructive to most biological molecules and are responsible for much of the damage inflicted by phagocytes on both microorganisms and surrounding tissues at sites of infection or inflammation. Increasing evidence suggests that the generation of oxygen metabolites plays an important role not only for perpetuation of chronic inflammation, but also for the etiology of other health problems i.e. ageing, cancer, ischemia, and radiationinduced injuries. The extent of tissue damage in inflammation may partly be the result of the balance between free radicals generated and the antioxidant/radical scavenger protective defence systems. The implication of oxygen free radicals in inflammation and future directions are briefly discussed in the present overview.
AB - When mammalian phagocytes encounter appropriate stimuli, highly reactive oxygen derived free radicals (superoxide and hydroxyl) and related species (hydrogen peroxide and hypochlorous acid) may be produced as a normal mechanism in the defence of the host against invading microorganisms. The radicals are destructive to most biological molecules and are responsible for much of the damage inflicted by phagocytes on both microorganisms and surrounding tissues at sites of infection or inflammation. Increasing evidence suggests that the generation of oxygen metabolites plays an important role not only for perpetuation of chronic inflammation, but also for the etiology of other health problems i.e. ageing, cancer, ischemia, and radiationinduced injuries. The extent of tissue damage in inflammation may partly be the result of the balance between free radicals generated and the antioxidant/radical scavenger protective defence systems. The implication of oxygen free radicals in inflammation and future directions are briefly discussed in the present overview.
KW - Free Radicals
KW - Humans
KW - Inflammation/immunology
KW - Phagocytes/immunology
M3 - Tidsskriftartikel
C2 - 2780275
VL - 104
SP - 216
EP - 218
JO - Nordisk medicin
JF - Nordisk medicin
SN - 0029-1420
IS - 8-9
ER -
ID: 218728938