Increasing seroprevalence of Clostridium difficile in an adult Danish general population
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Increasing seroprevalence of Clostridium difficile in an adult Danish general population. / Fenger, R V; Linneberg, A; Tvede, M; Ostergaard, C.
I: Epidemiology and Infection, Bind 137, Nr. 2, 2009, s. 278-83.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Increasing seroprevalence of Clostridium difficile in an adult Danish general population
AU - Fenger, R V
AU - Linneberg, A
AU - Tvede, M
AU - Ostergaard, C
N1 - Keywords: Adolescent; Adult; Aged; Antibodies, Bacterial; Clostridium difficile; Denmark; Humans; Middle Aged; Seroepidemiologic Studies; Young Adult
PY - 2009
Y1 - 2009
N2 - The incidence of Clostridium difficile-associated infections is increasing, but it remains to be defined whether any change in the seroprevalence of C. difficile has also occurred. In a population-based study of the general adult population, 734 subjects, aged 15-69 years, were examined on two occasions 8 years apart (1990 and 1998) for the presence of antibodies against C. difficile in serum. The overall seroprevalence of C. difficile increased significantly from 19% in 1990 to 27% in 1998 (P<0.0001). The seroprevalence increased with increasing age in both 1990 and 1998, but the increase was about four times higher in 1998 than in 1990. In conclusion, the observed increase in seroprevalence suggests a higher exposure to C. difficile in the general Danish adult population.
AB - The incidence of Clostridium difficile-associated infections is increasing, but it remains to be defined whether any change in the seroprevalence of C. difficile has also occurred. In a population-based study of the general adult population, 734 subjects, aged 15-69 years, were examined on two occasions 8 years apart (1990 and 1998) for the presence of antibodies against C. difficile in serum. The overall seroprevalence of C. difficile increased significantly from 19% in 1990 to 27% in 1998 (P<0.0001). The seroprevalence increased with increasing age in both 1990 and 1998, but the increase was about four times higher in 1998 than in 1990. In conclusion, the observed increase in seroprevalence suggests a higher exposure to C. difficile in the general Danish adult population.
U2 - 10.1017/S0950268808000800
DO - 10.1017/S0950268808000800
M3 - Journal article
C2 - 18503728
VL - 137
SP - 278
EP - 283
JO - Epidemiology and Infection
JF - Epidemiology and Infection
SN - 0950-2688
IS - 2
ER -
ID: 10928102