Increasing incidence and survival in oral cancer: a nationwide Danish study from 1980 to 2014
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Increasing incidence and survival in oral cancer : a nationwide Danish study from 1980 to 2014. / Karnov, Kirstine Kim Schmidt; Grønhøj, Christian; Jensen, David Hebbelstrup; Wessel, Irene; Charabi, Birgitte Wittenborg; Specht, Lena; Kjaer, Andreas; von Buchwald, Christian.
I: Acta Oncologica, Bind 56, Nr. 9, 2017, s. 1204-1209.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Increasing incidence and survival in oral cancer
T2 - a nationwide Danish study from 1980 to 2014
AU - Karnov, Kirstine Kim Schmidt
AU - Grønhøj, Christian
AU - Jensen, David Hebbelstrup
AU - Wessel, Irene
AU - Charabi, Birgitte Wittenborg
AU - Specht, Lena
AU - Kjaer, Andreas
AU - von Buchwald, Christian
PY - 2017
Y1 - 2017
N2 - Background: Oral carcinomas (OCs) make up a significant proportion of head and neck carcinomas (HNCs) and are an important cause of morbidity and mortality globally. The purpose of this population-based study was to determine trends in incidence and survival in OC in the Danish population from 1980 to 2014.Material and methods: This study covered all patients registered in the nationwide Danish cancer registry (DCR) in the period 1980–2014. Age-adjusted incidence rate (AAIR) per 100,000 and annual percentage change (APC) were evaluated. Also, 5-year overall survival (OS) was calculated with Cox regression analysis in relation to location, gender, age, and calendar year at diagnosis.Results: Altogether, 8299 patients with oral cancer were identified, 5062 (61%) of whom were males and 3237 (39%) were females. The median age at diagnosis was 63 years. The AAIR of patients with OC increased from 1.9 per 100,000 in 1980 to 3.5 per 100,000 in 2014, and we observed a significant increase in 5-year OS of 12% points (a relative increase of 38%) from the period 1980–1984 to 2005–2009. Women were found to have a better prognosis than men.Conclusions: We found an unexpected increase in the age-standardized incidence of OC during the last 30 years in Denmark, and also an improvement in survival. The 5-year OS was significantly better in recent years even when we adjusted the analysis for relevant covariates.
AB - Background: Oral carcinomas (OCs) make up a significant proportion of head and neck carcinomas (HNCs) and are an important cause of morbidity and mortality globally. The purpose of this population-based study was to determine trends in incidence and survival in OC in the Danish population from 1980 to 2014.Material and methods: This study covered all patients registered in the nationwide Danish cancer registry (DCR) in the period 1980–2014. Age-adjusted incidence rate (AAIR) per 100,000 and annual percentage change (APC) were evaluated. Also, 5-year overall survival (OS) was calculated with Cox regression analysis in relation to location, gender, age, and calendar year at diagnosis.Results: Altogether, 8299 patients with oral cancer were identified, 5062 (61%) of whom were males and 3237 (39%) were females. The median age at diagnosis was 63 years. The AAIR of patients with OC increased from 1.9 per 100,000 in 1980 to 3.5 per 100,000 in 2014, and we observed a significant increase in 5-year OS of 12% points (a relative increase of 38%) from the period 1980–1984 to 2005–2009. Women were found to have a better prognosis than men.Conclusions: We found an unexpected increase in the age-standardized incidence of OC during the last 30 years in Denmark, and also an improvement in survival. The 5-year OS was significantly better in recent years even when we adjusted the analysis for relevant covariates.
U2 - 10.1080/0284186X.2017.1307516
DO - 10.1080/0284186X.2017.1307516
M3 - Journal article
C2 - 28366106
VL - 56
SP - 1204
EP - 1209
JO - Acta Oncologica
JF - Acta Oncologica
SN - 1100-1704
IS - 9
ER -
ID: 188226121