Clonal cytopenia of undetermined significance (CCUS) is a condition characterized by the presence of persistent cytopenia in one or more blood cell lineages, accompanied by the detection of one or more somatic mutations associated with myeloid neoplasms in haematopoietic cells, with a variant allele frequency (VAF) of 2% or higher.1, 2 Patients with CCUS have an increased risk of developing myelodysplastic syndrome (MDS) or acute myeloid leukaemia. Numerous factors increase the risk of progression, including the VAF, the number and type of mutations.3-5 Several studies have highlighted molecular and clinical similarities between CCUS and low-risk MDS (LR-MDS) patients,6, 7 suggesting that CCUS represents an early manifestation of LR-MDS and underlining a biological continuum between these entities.