Increased beta rhythm as an indicator of inhibitory mechanisms in tourette syndrome
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
BACKGROUND: Inhibitory oscillatory mechanisms subserving tic compensation have been put forward in Tourette syndrome. Modulation of the beta rhythm (15-25 Hz) as the well-established oscillatory movement execution-inhibition indicator was tested during a cognitive-motor task in patients with Tourette syndrome.
METHODS: Performing a Go/NoGo task, 12 patients with Tourette syndrome and 12 matched controls were recorded using whole-head magnetoencephalography.
RESULTS: Compared to healthy participants, patients showed less beta suppression in the sensorimotor area and enhanced beta power in parieto-occipital brain regions contralaterally to the response hand. Average beta power and power gain correlated negatively with tic severity.
CONCLUSIONS: Increased motor inhibitory as well as visuomotor attentional processes are likely to subserve tic compensation. Correlational results suggest that stronger inhibitory compensation accompanies less tic severity. © 2016 International Parkinson and Movement Disorder Society.
Originalsprog | Engelsk |
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Tidsskrift | Movement disorders : official journal of the Movement Disorder Society |
Vol/bind | 31 |
Udgave nummer | 3 |
Sider (fra-til) | 384-392 |
Antal sider | 9 |
ISSN | 0885-3185 |
DOI | |
Status | Udgivet - mar. 2016 |
ID: 161182708