TY - JOUR

T1 - Increased 5-year risk of stroke, atrial fibrillation, acute coronary syndrome, and heart failure in out-of-hospital cardiac arrest survivors compared with population controls

T2 - A nationwide registry-based study

AU - Byrne, Christina

AU - Pareek, Manan

AU - Krogager, Maria Lukacs

AU - Ringgren, Kristian B.

AU - Wissenberg, Mads

AU - Folke, Fredrik

AU - Lippert, Freddy

AU - Gislason, Gunnar

AU - Køber, Lars

AU - Søgaard, Peter

AU - Lip, Gregory Y.H.

AU - Torp-Pedersen, Christian

AU - Kragholm, Kristian

N1 - Publisher Copyright: © 2021 The Author(s)

PY - 2021

Y1 - 2021

N2 - Aim: Long-term risks of stroke, atrial fibrillation, or flutter (AF), acute coronary syndrome (ACS), and heart failure (HF) among survivors of out-of-hospital cardiac arrest (OHCA) are unknown. We aimed to examine 5-year risks of these outcomes among 30-day survivors of OHCA. Methods: Thirty-day survivors of OHCA without a prior (or within 30 days after cardiac arrest) history of stroke, AF, ACS, or HF and population controls without a prior history of these conditions were identified using Danish nationwide registries. Five-year risks of stroke, AF, ACS, and HF standardized to the distributions of age, sex, and comorbidities among OHCA survivors and controls were obtained using multivariable regression. Results: Of 4,362 30-day OHCA-survivors, 1,051 were stroke-, AF-, ACS-, and HF-naïve and matched with controls using age, sex, and time of OHCA event. Absolute five-year risks for OHCA survivors vs. controls were for stroke: 6.3% [95% confidence interval (CI) 4.1–8.5] vs. 2.0% [1.6–2.5], AF: 7.9% [5.7–10.2] vs. 2.6% [2.1–3.1], ACS: 5.0% [3.2–6.8] vs. 1.5% [1.1–1.9], and HF: 12.7% [10.1–15.4] vs. 1.2% [0.9–1.6], respectively. Corresponding relative risks were 3.18 [95% CI 1.76–4.61] for stroke, 3.03 [1.93–4.14] for AF, 3.23 [1.69–4.77] for ACS, and 10.40 [6.57–14.13] for HF. Conclusion: When compared with population controls, OHCA survivors had significantly increased five-year risks of incident stroke, AF, ACS, and HF.

AB - Aim: Long-term risks of stroke, atrial fibrillation, or flutter (AF), acute coronary syndrome (ACS), and heart failure (HF) among survivors of out-of-hospital cardiac arrest (OHCA) are unknown. We aimed to examine 5-year risks of these outcomes among 30-day survivors of OHCA. Methods: Thirty-day survivors of OHCA without a prior (or within 30 days after cardiac arrest) history of stroke, AF, ACS, or HF and population controls without a prior history of these conditions were identified using Danish nationwide registries. Five-year risks of stroke, AF, ACS, and HF standardized to the distributions of age, sex, and comorbidities among OHCA survivors and controls were obtained using multivariable regression. Results: Of 4,362 30-day OHCA-survivors, 1,051 were stroke-, AF-, ACS-, and HF-naïve and matched with controls using age, sex, and time of OHCA event. Absolute five-year risks for OHCA survivors vs. controls were for stroke: 6.3% [95% confidence interval (CI) 4.1–8.5] vs. 2.0% [1.6–2.5], AF: 7.9% [5.7–10.2] vs. 2.6% [2.1–3.1], ACS: 5.0% [3.2–6.8] vs. 1.5% [1.1–1.9], and HF: 12.7% [10.1–15.4] vs. 1.2% [0.9–1.6], respectively. Corresponding relative risks were 3.18 [95% CI 1.76–4.61] for stroke, 3.03 [1.93–4.14] for AF, 3.23 [1.69–4.77] for ACS, and 10.40 [6.57–14.13] for HF. Conclusion: When compared with population controls, OHCA survivors had significantly increased five-year risks of incident stroke, AF, ACS, and HF.

KW - Acute coronary syndrome

KW - Atrial fibrillation and atrial flutter

KW - Heart failure

KW - Long-term risk

KW - Out-of-hospital cardiac arrest survivors

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=85118510331&partnerID=8YFLogxK

U2 - 10.1016/j.resuscitation.2021.10.024

DO - 10.1016/j.resuscitation.2021.10.024

M3 - Journal article

C2 - 34695442

AN - SCOPUS:85118510331

VL - 169

SP - 53

EP - 59

JO - Resuscitation

JF - Resuscitation

SN - 0300-9572

ER -