Incidence, prevalence, and risk of selected ocular disease in adults with atopic dermatitis
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Incidence, prevalence, and risk of selected ocular disease in adults with atopic dermatitis. / Thyssen, Jacob P; Toft, Peter B; Halling-Overgaard, Anne-Sofie; Gislason, Gunnar H; Skov, Lone; Egeberg, Alexander.
I: Journal of the American Academy of Dermatology, Bind 77, Nr. 2, 2017, s. 280-286.e1.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Incidence, prevalence, and risk of selected ocular disease in adults with atopic dermatitis
AU - Thyssen, Jacob P
AU - Toft, Peter B
AU - Halling-Overgaard, Anne-Sofie
AU - Gislason, Gunnar H
AU - Skov, Lone
AU - Egeberg, Alexander
N1 - Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
PY - 2017
Y1 - 2017
N2 - BACKGROUND: Ocular comorbidities are common in atopic dermatitis (AD) as the result of the disease itself or the use of medication. No large-scale epidemiologic data exist on the prevalence of ocular comorbidities in adults with AD.OBJECTIVES: We sought to examine the prevalence and risk of selected ocular comorbidities in adult patients with AD.METHODS: All Danish individuals ≥18 years of age were linked in nationwide registries. Adjusted hazard ratios (HRs) were estimated by means of Cox regression.RESULTS: A total of 5766 and 4272 adults were categorized as having mild and severe AD, respectively. At least 1 prescription of anti-inflammatory ocular agents was claimed in 12.0% and 18.9% of patients with mild and severe AD, respectively. In adjusted analysis, the HR of conjunctivitis was 1.48 (95% confidence interval [CI], 1.15-1.90) for mild AD and 1.95 (95% CI, 1.51-2.51) for severe AD. The HR of keratitis was 1.66 (95% CI, 1.15-2.40) for mild AD and 3.17 (95% CI, 2.31-4.35) for severe AD. For adults with severe AD, the HR for keratoconus was 10.01 (95% CI, 5.02-19.96). AD was associated with "cataract only" in individuals <50 years of age.LIMITATIONS: A limitation of the study is that observational studies cannot establish causality.CONCLUSIONS: Adults with AD had a significant and disease severity-dependent increased risk of development of conjunctivitis, keratitis, and keratoconus compared with that of the general population.
AB - BACKGROUND: Ocular comorbidities are common in atopic dermatitis (AD) as the result of the disease itself or the use of medication. No large-scale epidemiologic data exist on the prevalence of ocular comorbidities in adults with AD.OBJECTIVES: We sought to examine the prevalence and risk of selected ocular comorbidities in adult patients with AD.METHODS: All Danish individuals ≥18 years of age were linked in nationwide registries. Adjusted hazard ratios (HRs) were estimated by means of Cox regression.RESULTS: A total of 5766 and 4272 adults were categorized as having mild and severe AD, respectively. At least 1 prescription of anti-inflammatory ocular agents was claimed in 12.0% and 18.9% of patients with mild and severe AD, respectively. In adjusted analysis, the HR of conjunctivitis was 1.48 (95% confidence interval [CI], 1.15-1.90) for mild AD and 1.95 (95% CI, 1.51-2.51) for severe AD. The HR of keratitis was 1.66 (95% CI, 1.15-2.40) for mild AD and 3.17 (95% CI, 2.31-4.35) for severe AD. For adults with severe AD, the HR for keratoconus was 10.01 (95% CI, 5.02-19.96). AD was associated with "cataract only" in individuals <50 years of age.LIMITATIONS: A limitation of the study is that observational studies cannot establish causality.CONCLUSIONS: Adults with AD had a significant and disease severity-dependent increased risk of development of conjunctivitis, keratitis, and keratoconus compared with that of the general population.
KW - Adult
KW - Age Factors
KW - Aged
KW - Case-Control Studies
KW - Cataract/epidemiology
KW - Comorbidity
KW - Conjunctivitis/epidemiology
KW - Denmark/epidemiology
KW - Dermatitis, Atopic/epidemiology
KW - Female
KW - Humans
KW - Incidence
KW - Keratitis/epidemiology
KW - Keratoconus/epidemiology
KW - Male
KW - Middle Aged
KW - Prevalence
KW - Proportional Hazards Models
KW - Registries
KW - Risk Assessment
KW - Severity of Illness Index
U2 - 10.1016/j.jaad.2017.03.003
DO - 10.1016/j.jaad.2017.03.003
M3 - Journal article
C2 - 28601391
VL - 77
SP - 280-286.e1
JO - American Academy of Dermatology. Journal
JF - American Academy of Dermatology. Journal
SN - 0190-9622
IS - 2
ER -
ID: 197369919