Incidence of clinical outcomes in heart failure patients with and without advanced chronic kidney disease
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Incidence of clinical outcomes in heart failure patients with and without advanced chronic kidney disease. / Zahir Anjum, Deewa; Bonde, Anders N.; Fosbol, Emil; Hartwell Garred, Caroline; Gislason, Gunnar; Elmegaard, Mariam; Knigge, Pauline; Torp-Pedersen, Christian; Andersson, Charlotte; Pfeffer, Marc A.; Jhund, Pardeep S.; McMurray, John J.V.; Petrie, Mark C.; Kober, Lars; Schou, Morten.
I: ESC heart failure, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Incidence of clinical outcomes in heart failure patients with and without advanced chronic kidney disease
AU - Zahir Anjum, Deewa
AU - Bonde, Anders N.
AU - Fosbol, Emil
AU - Hartwell Garred, Caroline
AU - Gislason, Gunnar
AU - Elmegaard, Mariam
AU - Knigge, Pauline
AU - Torp-Pedersen, Christian
AU - Andersson, Charlotte
AU - Pfeffer, Marc A.
AU - Jhund, Pardeep S.
AU - McMurray, John J.V.
AU - Petrie, Mark C.
AU - Kober, Lars
AU - Schou, Morten
N1 - Publisher Copyright: © 2024 The Author(s). ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
PY - 2024
Y1 - 2024
N2 - Aims: Chronic kidney disease (CKD) is a well-established risk factor for heart failure (HF); however, patients with an estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2 have been systematically excluded from clinical trials. This study investigated the incidence of HF and kidney outcomes in HF patients with and without advanced CKD, that is, eGFR < 30. Methods: From nationwide registries, HF patients were identified from 2014 to 2018 and categorized into three groups according to baseline eGFR (eGFR ≥ 60, 60 > eGFR ≥ 30 and eGFR < 30). The incidence of primary outcomes (all-cause mortality, HF hospitalization, end-stage kidney disease and sustained 50% eGFR decline) was estimated using cumulative incidence functions. Results: Of the 21 959 HF patients included, the median age was 73.9 years, and 30% of patients had an eGFR between 30 and 60 and 7% had an eGFR < 30. The 4 year incidence of all-cause mortality was highest for patients with eGFR < 30 (28.3% for patients with eGFR ≥ 60, 51.6% for patients with 60 > eGFR ≥ 30 and 72.2% for patients with eGFR < 30). The 4 year incidence of HF hospitalization was comparable between the groups (25.8%, 29.8% and 26.1% for patients with eGFR ≥ 60, 60 > eGFR ≥ 30 and eGFR < 30, respectively). For patients with eGFR < 30, kidney outcomes were four times more often the first event than patients with eGFR > 30 (4 year incidence of kidney outcome as the first event was 5.0% for eGFR ≥ 60, 4.8% for 60 > eGFR ≥ 30 and 20.1% for eGFR < 30). Conclusions: Patients with advanced CKD had a higher incidence of mortality and poorer kidney outcomes than those without advanced CKD, but a similar incidence of HF hospitalizations.
AB - Aims: Chronic kidney disease (CKD) is a well-established risk factor for heart failure (HF); however, patients with an estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2 have been systematically excluded from clinical trials. This study investigated the incidence of HF and kidney outcomes in HF patients with and without advanced CKD, that is, eGFR < 30. Methods: From nationwide registries, HF patients were identified from 2014 to 2018 and categorized into three groups according to baseline eGFR (eGFR ≥ 60, 60 > eGFR ≥ 30 and eGFR < 30). The incidence of primary outcomes (all-cause mortality, HF hospitalization, end-stage kidney disease and sustained 50% eGFR decline) was estimated using cumulative incidence functions. Results: Of the 21 959 HF patients included, the median age was 73.9 years, and 30% of patients had an eGFR between 30 and 60 and 7% had an eGFR < 30. The 4 year incidence of all-cause mortality was highest for patients with eGFR < 30 (28.3% for patients with eGFR ≥ 60, 51.6% for patients with 60 > eGFR ≥ 30 and 72.2% for patients with eGFR < 30). The 4 year incidence of HF hospitalization was comparable between the groups (25.8%, 29.8% and 26.1% for patients with eGFR ≥ 60, 60 > eGFR ≥ 30 and eGFR < 30, respectively). For patients with eGFR < 30, kidney outcomes were four times more often the first event than patients with eGFR > 30 (4 year incidence of kidney outcome as the first event was 5.0% for eGFR ≥ 60, 4.8% for 60 > eGFR ≥ 30 and 20.1% for eGFR < 30). Conclusions: Patients with advanced CKD had a higher incidence of mortality and poorer kidney outcomes than those without advanced CKD, but a similar incidence of HF hospitalizations.
KW - chronic kidney disease
KW - epidemiology
KW - heart failure
KW - renal endpoints
U2 - 10.1002/ehf2.14933
DO - 10.1002/ehf2.14933
M3 - Journal article
C2 - 38978335
AN - SCOPUS:85197722460
JO - E S C Heart Failure
JF - E S C Heart Failure
SN - 2055-5822
ER -
ID: 398544553