Immunotherapy for metastatic colorectal cancer: Present status and new options
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Immunotherapy for metastatic colorectal cancer : Present status and new options. / Ellebaek, Eva; Andersen, Mads Hald; Svane, Inge Marie; Straten, Per Thor.
I: Scandinavian Journal of Gastroenterology, Bind 47, Nr. 3, 2012, s. 315-24.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Immunotherapy for metastatic colorectal cancer
T2 - Present status and new options
AU - Ellebaek, Eva
AU - Andersen, Mads Hald
AU - Svane, Inge Marie
AU - Straten, Per Thor
PY - 2012
Y1 - 2012
N2 - Although no immunotherapeutic treatment is approved for colorectal cancer (CRC) patients, promising results from clinical trials suggest that several immunotherapeutic strategies may prove efficacious and applicable to this group of patients. This review describes the immunogenicity of CRC and presents the most interesting strategies investigated so far: cancer vaccination including antigen-defined vaccination and dendritic cell vaccination, chemo-immunotherapy, and adoptive cell transfer. Future treatment options as well as the possibility of combining existing therapies will be discussed along with the challenges presented by tumor escape mechanisms.
AB - Although no immunotherapeutic treatment is approved for colorectal cancer (CRC) patients, promising results from clinical trials suggest that several immunotherapeutic strategies may prove efficacious and applicable to this group of patients. This review describes the immunogenicity of CRC and presents the most interesting strategies investigated so far: cancer vaccination including antigen-defined vaccination and dendritic cell vaccination, chemo-immunotherapy, and adoptive cell transfer. Future treatment options as well as the possibility of combining existing therapies will be discussed along with the challenges presented by tumor escape mechanisms.
U2 - 10.3109/00365521.2012.640831
DO - 10.3109/00365521.2012.640831
M3 - Journal article
C2 - 22214467
VL - 47
SP - 315
EP - 324
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
SN - 0036-5521
IS - 3
ER -
ID: 48579825