IgE antibodies to alpha-gal in the general adult population: relationship with tick bites, atopy, and cat ownership
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
IgE antibodies to alpha-gal in the general adult population : relationship with tick bites, atopy, and cat ownership. / Gonzalez-Quintela, A; Dam Laursen, A S; Vidal, C; Skaaby, Tea; Gude, F; Linneberg, A.
I: Clinical and Experimental Allergy, Bind 44, Nr. 8, 08.2014, s. 1061–1068.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - IgE antibodies to alpha-gal in the general adult population
T2 - relationship with tick bites, atopy, and cat ownership
AU - Gonzalez-Quintela, A
AU - Dam Laursen, A S
AU - Vidal, C
AU - Skaaby, Tea
AU - Gude, F
AU - Linneberg, A
N1 - © 2014 John Wiley & Sons Ltd.
PY - 2014/8
Y1 - 2014/8
N2 - BACKGROUND: The carbohydrate alpha-gal epitope is present in many animal proteins, including those of red meat and animal immunoglobulins, such as cat IgA. Systemic anaphylaxis to the alpha-gal epitope has recently been described.OBJECTIVE: To investigate and compare the prevalence of alpha-gal-specific (s)IgE and its associated factors in the general adult population from two separated (Northern and Southern) European regions (Denmark and Spain, respectively).METHODS: Cross-sectional study of 2297 and 444 randomly selected adults from 11 municipalities in Denmark and one in Spain. Alpha-gal sIgE was assessed by ImmunoCAP to bovine thyroglobulin. Additional assessments included a panel of skin prick test (SPT) to common aeroallergens and epidemiological factors, including the history of tick bites in the Danish series.RESULTS: The prevalence of positive (≥ 0.1 kUA /L) sIgE to alpha-gal was 5.5% and 8.1% in the Danish and Spanish series, respectively. The prevalence of sIgE ≥ 0.35 kUA /L was 1.8% and 2.2% in Denmark and Spain, respectively. Alpha-gal sIgE positivity was associated with pet ownership in both series and, particularly, cat ownership (data available in the Danish series). Alpha-gal sIgE positivity was associated with atopy (SPT positivity) in both series, although it was not associated with SPT positivity to cat or dog dander. Alpha-gal sIgE positivity was strongly associated with a history of tick bites.CONCLUSIONS AND CLINICAL RELEVANCE: The prevalence of alpha-gal sIgE antibodies in these general adult European populations is similarly low. The presence of alpha-gal sIgE antibodies is associated with a history of tick bites, atopy, and cat ownership.
AB - BACKGROUND: The carbohydrate alpha-gal epitope is present in many animal proteins, including those of red meat and animal immunoglobulins, such as cat IgA. Systemic anaphylaxis to the alpha-gal epitope has recently been described.OBJECTIVE: To investigate and compare the prevalence of alpha-gal-specific (s)IgE and its associated factors in the general adult population from two separated (Northern and Southern) European regions (Denmark and Spain, respectively).METHODS: Cross-sectional study of 2297 and 444 randomly selected adults from 11 municipalities in Denmark and one in Spain. Alpha-gal sIgE was assessed by ImmunoCAP to bovine thyroglobulin. Additional assessments included a panel of skin prick test (SPT) to common aeroallergens and epidemiological factors, including the history of tick bites in the Danish series.RESULTS: The prevalence of positive (≥ 0.1 kUA /L) sIgE to alpha-gal was 5.5% and 8.1% in the Danish and Spanish series, respectively. The prevalence of sIgE ≥ 0.35 kUA /L was 1.8% and 2.2% in Denmark and Spain, respectively. Alpha-gal sIgE positivity was associated with pet ownership in both series and, particularly, cat ownership (data available in the Danish series). Alpha-gal sIgE positivity was associated with atopy (SPT positivity) in both series, although it was not associated with SPT positivity to cat or dog dander. Alpha-gal sIgE positivity was strongly associated with a history of tick bites.CONCLUSIONS AND CLINICAL RELEVANCE: The prevalence of alpha-gal sIgE antibodies in these general adult European populations is similarly low. The presence of alpha-gal sIgE antibodies is associated with a history of tick bites, atopy, and cat ownership.
KW - Animals
KW - Antibody Specificity
KW - Cats
KW - Cross-Sectional Studies
KW - Denmark
KW - Humans
KW - Hypersensitivity
KW - Immunoglobulin E
KW - Population Surveillance
KW - Prevalence
KW - Questionnaires
KW - Seroepidemiologic Studies
KW - Spain
KW - Tick Bites
KW - Trisaccharides
U2 - 10.1111/cea.12326
DO - 10.1111/cea.12326
M3 - Journal article
C2 - 24750173
VL - 44
SP - 1061
EP - 1068
JO - Clinical Allergy
JF - Clinical Allergy
SN - 0954-7894
IS - 8
ER -
ID: 138431302