IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. / Gyrd-Hansen, Mads; Meier, Pascal.
I: Nature Reviews. Cancer, Bind 10, Nr. 8, 2010, s. 561-74.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer
AU - Gyrd-Hansen, Mads
AU - Meier, Pascal
N1 - Keywords: Animals; Apoptosis; Caspases; Humans; Inflammation; Inhibitor of Apoptosis Proteins; Lymphoma, B-Cell, Marginal Zone; NF-kappa B; Neoplasm Metastasis; Neoplasms; Signal Transduction; Toll-Like Receptors; Ubiquitin
PY - 2010
Y1 - 2010
N2 - The realization that alterations in inhibitor of apoptosis (IAP) proteins are found in many types of human cancer and are associated with chemoresistance, disease progression and poor prognosis, has sparked a worldwide frenzy in the development of small pharmacological inhibitors of IAPs. The development of such inhibitors has radically changed our knowledge of the signalling processes that are regulated by IAPs. Recent studies indicate that IAPs not only regulate caspases and apoptosis, but also modulate inflammatory signalling and immunity, mitogenic kinase signalling, proliferation and mitosis, as well as cell invasion and metastasis.
AB - The realization that alterations in inhibitor of apoptosis (IAP) proteins are found in many types of human cancer and are associated with chemoresistance, disease progression and poor prognosis, has sparked a worldwide frenzy in the development of small pharmacological inhibitors of IAPs. The development of such inhibitors has radically changed our knowledge of the signalling processes that are regulated by IAPs. Recent studies indicate that IAPs not only regulate caspases and apoptosis, but also modulate inflammatory signalling and immunity, mitogenic kinase signalling, proliferation and mitosis, as well as cell invasion and metastasis.
U2 - 10.1038/nrc2889
DO - 10.1038/nrc2889
M3 - Review
C2 - 20651737
VL - 10
SP - 561
EP - 574
JO - Nature Reviews. Cancer
JF - Nature Reviews. Cancer
SN - 1474-175X
IS - 8
ER -
ID: 22239620