Hypoattenuated leaflet thickening (HALT) and reduced leaflet motion (RELM) of aortic bioprostheses: An imaging finding or a complication?

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Transcatheter aortic valve implantation is a safe and effective therapy for patients with symptomatic severe aortic stenosis, with randomized data demonstrating outcomes at least equivalent to surgical aortic valve replacement across the spectrum of surgical risk. There has been substantial recent interest in the occurrence of hypoattenuated leaflet thickening and reduced leaflet motion, which are imaging features detected on computed tomography of patients who have received aortic bioprostheses. These phenomena may represent subclinical leaflet thrombosis with theoretical potential downstream effects on valve durability or thrombotic complications in the form of stroke. This review will discuss definitions, predictors, mechanisms, diagnosis, and natural history. We will also examine the frequency with which hypoattenuated leaflet thickening and reduced leaflet motion occur after both transcatheter and surgical aortic bioprostheses, and the clinical implications and potential impact on valve function, as well as strategies for prophylaxis and treatment.

OriginalsprogEngelsk
TidsskriftProgress in Cardiovascular Diseases
Vol/bind72
Sider (fra-til)78-83
Antal sider6
ISSN0033-0620
DOI
StatusUdgivet - 2022

Bibliografisk note

Funding Information:
Dr. Makkar has received research grants from Edwards Lifesciences, Abbott, Medtronic, and Boston Scientific ; has served as National Principal Investigator for Portico (Abbott) and Acurate ( Boston Scientific ) U.S. investigation device exemption trials; has received personal proctoring fees from Edwards Lifesciences ; and has received travel support from Edwards Lifesciences, Abbott, and Boston Scientific .

Publisher Copyright:
© 2022 Elsevier Inc.

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