Hyperglycaemia protects against neuronal injury around experimental brain infarcts.
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Hyperglycaemia protects against neuronal injury around experimental brain infarcts. / Nedergaard, M; Gjedde, A; Diemer, N H.
I: Neurological Research, Bind 9, Nr. 4, 1987, s. 241-4.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Hyperglycaemia protects against neuronal injury around experimental brain infarcts.
AU - Nedergaard, M
AU - Gjedde, A
AU - Diemer, N H
PY - 1987
Y1 - 1987
N2 - Regional glucose utilization was measured in the rat brain after occlusion of the middle cerebral artery. Normoglycaemic rat had increased glucose use in the cerebral cortex adjacent to the infarct. A fraction of the nerve cells were irreversibly injured in this region. In hyperglycaemic rats, the glucose metabolism remained normal and no nerve cell loss was found around the infarct. The findings indicate that hyperglycaemia protects against nerve cell injury in the areas next to experimental brain infarcts.
AB - Regional glucose utilization was measured in the rat brain after occlusion of the middle cerebral artery. Normoglycaemic rat had increased glucose use in the cerebral cortex adjacent to the infarct. A fraction of the nerve cells were irreversibly injured in this region. In hyperglycaemic rats, the glucose metabolism remained normal and no nerve cell loss was found around the infarct. The findings indicate that hyperglycaemia protects against nerve cell injury in the areas next to experimental brain infarcts.
M3 - Journal article
C2 - 2895900
VL - 9
SP - 241
EP - 244
JO - Neurological Research
JF - Neurological Research
SN - 0161-6412
IS - 4
ER -
ID: 14946171