How long can bacteriophage λ change its mind?
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How long can bacteriophage λ change its mind? / Semsey, Szabolcs; Campion, Christopher; Mohamed, Abdu; Svenningsen, Sine Lo.
I: Bacteriophage, Bind 5, Nr. 1, 16.10.2015, s. e1012930.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - How long can bacteriophage λ change its mind?
AU - Semsey, Szabolcs
AU - Campion, Christopher
AU - Mohamed, Abdu
AU - Svenningsen, Sine Lo
PY - 2015/10/16
Y1 - 2015/10/16
N2 - A key event in the lifecycle of a temperate bacteriophage is the choice between lysis and lysogeny upon infection of a susceptible host cell. In a recent paper, we showed that a prolonged period exists after the decision to lysogenize, during which bacteriophage λ can abandon the initial decision, and instead develop lytically, as a response to the accumulation of the late lytic regulatory protein Q. Here, we present evidence that expression of Q does not induce replication of λ DNA, suggesting that the DNA to be packaged into the resulting phage progeny was already present at the time of the initial decision to lysogenize. We summarize our findings in a working model of the key determinants of the duration of the post-decision period during which it is possible for the infected cell to switch from the lysogeny decision to successful lytic development.
AB - A key event in the lifecycle of a temperate bacteriophage is the choice between lysis and lysogeny upon infection of a susceptible host cell. In a recent paper, we showed that a prolonged period exists after the decision to lysogenize, during which bacteriophage λ can abandon the initial decision, and instead develop lytically, as a response to the accumulation of the late lytic regulatory protein Q. Here, we present evidence that expression of Q does not induce replication of λ DNA, suggesting that the DNA to be packaged into the resulting phage progeny was already present at the time of the initial decision to lysogenize. We summarize our findings in a working model of the key determinants of the duration of the post-decision period during which it is possible for the infected cell to switch from the lysogeny decision to successful lytic development.
U2 - 10.1080/21597081.2015.1012930
DO - 10.1080/21597081.2015.1012930
M3 - Journal article
C2 - 26459429
VL - 5
SP - e1012930
JO - Bacteriophage
JF - Bacteriophage
SN - 2159-7073
IS - 1
ER -
ID: 163917127