How inert is single‐stranded DNA towards DNA‐stabilized silver nanoclusters? A case study.
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How inert is single‐stranded DNA towards DNA‐stabilized silver nanoclusters? A case study. / Rück, Vanessa; Cerretani, Cecilia; Vosch, Tom.
I: ChemPhotoChem, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - How inert is single‐stranded DNA towards DNA‐stabilized silver nanoclusters? A case study.
AU - Rück, Vanessa
AU - Cerretani, Cecilia
AU - Vosch, Tom
PY - 2024
Y1 - 2024
N2 - A case study, detailing the effect of different DNA strands on a NIR-emitting DNA-stabilized silver nanocluster (DNA-AgNC), is reported. The presence of single-stranded DNA oligomers was found to adversely affect the chemical stability of (DNA)2[Ag16Cl2]8+ with distinct degrees of destruction depending on the DNA sequence. To increase the chemical stability of the DNA-AgNC, we implemented two protection strategies. First, hybridization of the bare DNA strands with the corresponding complementary sequences dramatically reduced the destruction of (DNA)2[Ag16Cl2]8+, as demonstrated by the decreased drops in both the absorption and emission spectra. Secondly, passivation of the bare DNA oligomers with silver cations left (DNA)2[Ag16Cl2]8+ intact. Our investigation can thus provide an easy-to-implement approach to discover DNA sequences that are intrinsically less reactive towards preformed DNA-AgNCs, and give an idea on how to protect DNA-AgNCs from bare DNA strands.
AB - A case study, detailing the effect of different DNA strands on a NIR-emitting DNA-stabilized silver nanocluster (DNA-AgNC), is reported. The presence of single-stranded DNA oligomers was found to adversely affect the chemical stability of (DNA)2[Ag16Cl2]8+ with distinct degrees of destruction depending on the DNA sequence. To increase the chemical stability of the DNA-AgNC, we implemented two protection strategies. First, hybridization of the bare DNA strands with the corresponding complementary sequences dramatically reduced the destruction of (DNA)2[Ag16Cl2]8+, as demonstrated by the decreased drops in both the absorption and emission spectra. Secondly, passivation of the bare DNA oligomers with silver cations left (DNA)2[Ag16Cl2]8+ intact. Our investigation can thus provide an easy-to-implement approach to discover DNA sequences that are intrinsically less reactive towards preformed DNA-AgNCs, and give an idea on how to protect DNA-AgNCs from bare DNA strands.
U2 - 10.1002/cptc.202400014
DO - 10.1002/cptc.202400014
M3 - Journal article
JO - ChemPhotoChem
JF - ChemPhotoChem
SN - 2367-0932
M1 - e202400014
ER -
ID: 391676282