Household dampness and microbial exposure related to allergy and respiratory health in Danish adults
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Household dampness and microbial exposure related to allergy and respiratory health in Danish adults. / Holst, G. Juel; Porneki, Ad; Lindgreen, J.; Thuesen, B.; Bonlokke, J.; Hyvarinen, A.; Elholm, G.; Ostergaard, K.; Loft, S.; Brooks, C.; Douwes, J.; Linneberg, A.; Sigsgaard, T.
I: European Clinical Respiratory Journal, Bind 7, Nr. 1, 1706235, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Household dampness and microbial exposure related to allergy and respiratory health in Danish adults
AU - Holst, G. Juel
AU - Porneki, Ad
AU - Lindgreen, J.
AU - Thuesen, B.
AU - Bonlokke, J.
AU - Hyvarinen, A.
AU - Elholm, G.
AU - Ostergaard, K.
AU - Loft, S.
AU - Brooks, C.
AU - Douwes, J.
AU - Linneberg, A.
AU - Sigsgaard, T.
PY - 2020
Y1 - 2020
N2 - BackgroundIndoor dampness has consistently been associated with respiratory symptoms and exacerbations. The causal mechanisms may involve increased microbial exposures. However, the evidence regarding the influence of indoor microbial exposures under damp- and non-damp conditions on the risk of asthma and allergy has been inconclusive.ObjectiveThe aim of this study was to investigate the association between dampness and microbial exposure with allergy and respiratory health in Danish adults using a cross-sectional design.MethodsFrom 1,866 participants of the Health2006 cohort, we selected three non-overlapping groups: 196 at random, 107 with confirmed atopy, and 99 without atopy. Bedroom dust was sampled using electrostatic dust fall collectors and analysed for endotoxin, β-(1,3)-D-glucan, 19 microbial species or groups, and total fungal load. Household moisture-related problems and asthma were self-reported by questionnaire. Atopy was determined by skin-prick-testing and lung function was measured by spirometry.ResultsHousehold moisture damage was positively associated with asthma outcomes, although this was statistically significant only in atopics for self-reported asthma (odds ratio (OR) 3.52; 95%CI 1.01–12.7). Mould odor was positively associated with wheezing (OR 6.05; 95%CI 1.19–30.7) in atopics. Inconsistent associations were found for individual microbial exposures and health outcomes. Inverse associations were observed between microbial diversity and rhinitis in the random sample and both doctor-diagnosed and self-reported asthma in non-atopics.ConclusionsIn conclusion, our findings suggest that household moisture damage may increase the risk of asthma and wheeze with mould odor in atopics. In addition, asthma and allergy may be affected by the indoor microbial composition in urban domestic environments. Further studies are needed to identify and understand the causal agents and underlying mechanisms behind the potential effects of environmental microbial exposure on human health.
AB - BackgroundIndoor dampness has consistently been associated with respiratory symptoms and exacerbations. The causal mechanisms may involve increased microbial exposures. However, the evidence regarding the influence of indoor microbial exposures under damp- and non-damp conditions on the risk of asthma and allergy has been inconclusive.ObjectiveThe aim of this study was to investigate the association between dampness and microbial exposure with allergy and respiratory health in Danish adults using a cross-sectional design.MethodsFrom 1,866 participants of the Health2006 cohort, we selected three non-overlapping groups: 196 at random, 107 with confirmed atopy, and 99 without atopy. Bedroom dust was sampled using electrostatic dust fall collectors and analysed for endotoxin, β-(1,3)-D-glucan, 19 microbial species or groups, and total fungal load. Household moisture-related problems and asthma were self-reported by questionnaire. Atopy was determined by skin-prick-testing and lung function was measured by spirometry.ResultsHousehold moisture damage was positively associated with asthma outcomes, although this was statistically significant only in atopics for self-reported asthma (odds ratio (OR) 3.52; 95%CI 1.01–12.7). Mould odor was positively associated with wheezing (OR 6.05; 95%CI 1.19–30.7) in atopics. Inconsistent associations were found for individual microbial exposures and health outcomes. Inverse associations were observed between microbial diversity and rhinitis in the random sample and both doctor-diagnosed and self-reported asthma in non-atopics.ConclusionsIn conclusion, our findings suggest that household moisture damage may increase the risk of asthma and wheeze with mould odor in atopics. In addition, asthma and allergy may be affected by the indoor microbial composition in urban domestic environments. Further studies are needed to identify and understand the causal agents and underlying mechanisms behind the potential effects of environmental microbial exposure on human health.
KW - Moisture and mould
KW - household microbial exposure
KW - endotoxin
KW - house dust
KW - respiratory health
KW - allergy
KW - asthma
U2 - 10.1080/20018525.2019.1706235
DO - 10.1080/20018525.2019.1706235
M3 - Journal article
C2 - 32128077
VL - 7
JO - European Clinical Respiratory Journal
JF - European Clinical Respiratory Journal
SN - 2001-8525
IS - 1
M1 - 1706235
ER -
ID: 235406530