Hourly staircase sprinting exercise “snacks” improve femoral artery shear patterns but not flow-mediated dilation or cerebrovascular regulation: A pilot study
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Hourly staircase sprinting exercise “snacks” improve femoral artery shear patterns but not flow-mediated dilation or cerebrovascular regulation : A pilot study. / Caldwell, Hannah Grace; Coombs, Geoff B; Rafiei, Hossein; Ainslie, Philip N; Little, Jonathan P.
I: Applied Physiology, Nutrition and Metabolism, Bind 46, Nr. 5, 2021, s. 521-529.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Hourly staircase sprinting exercise “snacks” improve femoral artery shear patterns but not flow-mediated dilation or cerebrovascular regulation
T2 - A pilot study
AU - Caldwell, Hannah Grace
AU - Coombs, Geoff B
AU - Rafiei, Hossein
AU - Ainslie, Philip N
AU - Little, Jonathan P
N1 - Publisher Copyright: © 2021, Canadian Science Publishing. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Healthy males (n = 10; age: 24 ± 4 years; bodymass index: 24 6 2 kg·m-2) completed 2 randomized conditions separated by ≥48 h involving 6-8.5 h of sitting with (“stair snacks”) and without (sedentary) hourly staircase sprint interval exercise (~14-20 s each). Resting blood flow and shear rates were measured in the femoral artery, internal carotid artery, and vertebral artery (Duplex ultrasound). Flow-mediated dilation (FMD) was quantified as an index of peripheral endothelial function in the femoral artery. Neurovascular coupling (NVC; regional blood flow response to local increases in cerebral metabolism) was assessed in the posterior cerebral artery (transcranial Doppler ultrasound). Femoral artery hemodynamics were higher following the active trial with no change in the sedentary trial, including blood flow (+32 6 23% vs. -10 ± 28%; P = 0.015 and P = 0.253, respectively), vascular conductance (+32 ± 27% vs. _15 6 26%; P = 0.012 and P = 0.098, respectively), and mean shear rate (+17 6 8% vs. -8 ± 28%; P = 0.004 and P = 0.310, respectively). The change in FMD was not different within or between conditions (P = 0.184). Global cerebral blood flow (CBF), conductance, shear patterns, and NVC were not different within or between conditions (all P > 0.05). Overall, exercise “stair snacks” improve femoral artery blood flow and shear patterns but not peripheral (e.g., FMD) or cerebral (e.g., CBF and NVC) vascular function following prolonged sitting. The study was registered at Clinical- Trials.gov (NCT03374436).
AB - Healthy males (n = 10; age: 24 ± 4 years; bodymass index: 24 6 2 kg·m-2) completed 2 randomized conditions separated by ≥48 h involving 6-8.5 h of sitting with (“stair snacks”) and without (sedentary) hourly staircase sprint interval exercise (~14-20 s each). Resting blood flow and shear rates were measured in the femoral artery, internal carotid artery, and vertebral artery (Duplex ultrasound). Flow-mediated dilation (FMD) was quantified as an index of peripheral endothelial function in the femoral artery. Neurovascular coupling (NVC; regional blood flow response to local increases in cerebral metabolism) was assessed in the posterior cerebral artery (transcranial Doppler ultrasound). Femoral artery hemodynamics were higher following the active trial with no change in the sedentary trial, including blood flow (+32 6 23% vs. -10 ± 28%; P = 0.015 and P = 0.253, respectively), vascular conductance (+32 ± 27% vs. _15 6 26%; P = 0.012 and P = 0.098, respectively), and mean shear rate (+17 6 8% vs. -8 ± 28%; P = 0.004 and P = 0.310, respectively). The change in FMD was not different within or between conditions (P = 0.184). Global cerebral blood flow (CBF), conductance, shear patterns, and NVC were not different within or between conditions (all P > 0.05). Overall, exercise “stair snacks” improve femoral artery blood flow and shear patterns but not peripheral (e.g., FMD) or cerebral (e.g., CBF and NVC) vascular function following prolonged sitting. The study was registered at Clinical- Trials.gov (NCT03374436).
KW - Cerebral blood flow
KW - Duplex ultrasound
KW - Exercise breaks
KW - Flow-mediated dilation
KW - Prolonged sitting
KW - Vascular function
UR - http://www.scopus.com/inward/record.url?scp=85106008712&partnerID=8YFLogxK
U2 - 10.1139/apnm-2020-0562
DO - 10.1139/apnm-2020-0562
M3 - Journal article
C2 - 33242251
AN - SCOPUS:85106008712
VL - 46
SP - 521
EP - 529
JO - Applied Physiology, Nutrition and Metabolism
JF - Applied Physiology, Nutrition and Metabolism
SN - 1715-5312
IS - 5
ER -
ID: 270673430