Heterogenous migraine aura symptoms correlate with visual cortex functional magnetic resonance imaging responses
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Heterogenous migraine aura symptoms correlate with visual cortex functional magnetic resonance imaging responses. / Arngrim, Nanna; Hougaard, Anders; Ahmadi, Khazar; Vestergaard, Mark Bitsch; Schytz, Henrik Winther; Amin, Faisal Mohammad; Larsson, Henrik Bo Wiberg; Olesen, Jes; Hoffmann, Michael B.; Ashina, Messoud.
I: Annals of Neurology, Bind 82, Nr. 6, 12.2017, s. 925-939.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Heterogenous migraine aura symptoms correlate with visual cortex functional magnetic resonance imaging responses
AU - Arngrim, Nanna
AU - Hougaard, Anders
AU - Ahmadi, Khazar
AU - Vestergaard, Mark Bitsch
AU - Schytz, Henrik Winther
AU - Amin, Faisal Mohammad
AU - Larsson, Henrik Bo Wiberg
AU - Olesen, Jes
AU - Hoffmann, Michael B.
AU - Ashina, Messoud
PY - 2017/12
Y1 - 2017/12
N2 - Objective: Migraine aura is sparsely studied due to the highly challenging task of capturing patients during aura. Cortical spreading depression (CSD) is likely the underlying phenomenon of aura. The possible correlation between the multifaceted phenomenology of aura symptoms and the effects of CSD on the brain has not been ascertained. Methods: Five migraine patients were studied during various forms of aura symptoms induced by hypoxia, sham hypoxia, or physical exercise with concurrent photostimulation. The blood oxygenation level–dependent (BOLD) functional magnetic resonance imaging (fMRI) signal response to visual stimulation was measured in retinotopic mapping–defined visual cortex areas V1 to V4. Results: We found reduced BOLD response in patients reporting scotoma and increased response in patients who only experienced positive symptoms. Furthermore, patients with bilateral visual symptoms had corresponding bihemispherical changes in BOLD response. Interpretation: These findings suggest that different aura symptoms reflect different types of cerebral dysfunction, which correspond to specific changes in BOLD signal reactivity. Furthermore, we provide evidence of bilateral CSD recorded by fMRI during bilateral aura symptoms. Ann Neurol 2017;82:925–939.
AB - Objective: Migraine aura is sparsely studied due to the highly challenging task of capturing patients during aura. Cortical spreading depression (CSD) is likely the underlying phenomenon of aura. The possible correlation between the multifaceted phenomenology of aura symptoms and the effects of CSD on the brain has not been ascertained. Methods: Five migraine patients were studied during various forms of aura symptoms induced by hypoxia, sham hypoxia, or physical exercise with concurrent photostimulation. The blood oxygenation level–dependent (BOLD) functional magnetic resonance imaging (fMRI) signal response to visual stimulation was measured in retinotopic mapping–defined visual cortex areas V1 to V4. Results: We found reduced BOLD response in patients reporting scotoma and increased response in patients who only experienced positive symptoms. Furthermore, patients with bilateral visual symptoms had corresponding bihemispherical changes in BOLD response. Interpretation: These findings suggest that different aura symptoms reflect different types of cerebral dysfunction, which correspond to specific changes in BOLD signal reactivity. Furthermore, we provide evidence of bilateral CSD recorded by fMRI during bilateral aura symptoms. Ann Neurol 2017;82:925–939.
U2 - 10.1002/ana.25096
DO - 10.1002/ana.25096
M3 - Journal article
C2 - 29130510
AN - SCOPUS:85037371421
VL - 82
SP - 925
EP - 939
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 6
ER -
ID: 189663765