Has the time come to stop routine N-acetylcysteine treatment in young children in Denmark? A review of 300 suspected paracetamol overdoses in children aged 0–6 years

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Standard

Has the time come to stop routine N-acetylcysteine treatment in young children in Denmark? A review of 300 suspected paracetamol overdoses in children aged 0–6 years. / Gade, Christina; Bøgevig, Søren; Daoud, Alaa; Mathiesen, Pernille R.; Chrstensen, Mikkel B.; Dalhoff, Kim P.; Petersen, Tonny S.

I: Acta Paediatrica, International Journal of Paediatrics, Bind 111, Nr. 3, 2022, s. 667–674.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Gade, C, Bøgevig, S, Daoud, A, Mathiesen, PR, Chrstensen, MB, Dalhoff, KP & Petersen, TS 2022, 'Has the time come to stop routine N-acetylcysteine treatment in young children in Denmark? A review of 300 suspected paracetamol overdoses in children aged 0–6 years', Acta Paediatrica, International Journal of Paediatrics, bind 111, nr. 3, s. 667–674. https://doi.org/10.1111/apa.16185

APA

Gade, C., Bøgevig, S., Daoud, A., Mathiesen, P. R., Chrstensen, M. B., Dalhoff, K. P., & Petersen, T. S. (2022). Has the time come to stop routine N-acetylcysteine treatment in young children in Denmark? A review of 300 suspected paracetamol overdoses in children aged 0–6 years. Acta Paediatrica, International Journal of Paediatrics, 111(3), 667–674. https://doi.org/10.1111/apa.16185

Vancouver

Gade C, Bøgevig S, Daoud A, Mathiesen PR, Chrstensen MB, Dalhoff KP o.a. Has the time come to stop routine N-acetylcysteine treatment in young children in Denmark? A review of 300 suspected paracetamol overdoses in children aged 0–6 years. Acta Paediatrica, International Journal of Paediatrics. 2022;111(3):667–674. https://doi.org/10.1111/apa.16185

Author

Gade, Christina ; Bøgevig, Søren ; Daoud, Alaa ; Mathiesen, Pernille R. ; Chrstensen, Mikkel B. ; Dalhoff, Kim P. ; Petersen, Tonny S. / Has the time come to stop routine N-acetylcysteine treatment in young children in Denmark? A review of 300 suspected paracetamol overdoses in children aged 0–6 years. I: Acta Paediatrica, International Journal of Paediatrics. 2022 ; Bind 111, Nr. 3. s. 667–674.

Bibtex

@article{cf70b1fd3d6948f6a6c3bcf08bceeac4,
title = "Has the time come to stop routine N-acetylcysteine treatment in young children in Denmark?: A review of 300 suspected paracetamol overdoses in children aged 0–6 years",
abstract = "Aim: To evaluate the prevalence of potentially hepatoxic paracetamol ingestion and associated N-acetylcysteine treatment in young children suspected of paracetamol poisoning. Methods: A retrospective cohort study of children aged 0–6 years suspected of paracetamol poisoning with a related plasma-paracetamol measurement in the Capital Region of Denmark in the period 2010–2017. Data from the clinical laboratory system were linked to data from electronic patient records via the unique identification number given to all Danish residents. Results: Of 297 children included, suspected single paracetamol overdoses were present in 281 (95%). Sixty-nine per cent were treated with N-acetylcysteine, and the mean treatment period was 20.3 h (SD 20.8). A maximum of 6 (2%) of the children suspected of single overdose had plasma-paracetamol concentrations that exceeded the recommended treatment thresholds. No cases of severe hepatotoxicity were registered. Adverse events to N-acetylcysteine-treatment were registered in 3 (2%) children including one anaphylactoid reaction (0.5%). Conclusion: This study shows that initiating N-acetylcysteine as a {\textquoteleft}one size fit all{\textquoteright} treatment regimen in all children aged 0–6 years with a suspected single paracetamol overdose leads to substantial overtreatment. The data support that it is feasible to initiate N-acetylcysteine within 10 h based on an early plasma-paracetamol test.",
author = "Christina Gade and S{\o}ren B{\o}gevig and Alaa Daoud and Mathiesen, {Pernille R.} and Chrstensen, {Mikkel B.} and Dalhoff, {Kim P.} and Petersen, {Tonny S.}",
note = "Publisher Copyright: {\textcopyright} 2021 Foundation Acta P{\ae}diatrica. Published by John Wiley & Sons Ltd",
year = "2022",
doi = "10.1111/apa.16185",
language = "English",
volume = "111",
pages = "667–674",
journal = "Acta Paediatrica",
issn = "0803-5253",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Has the time come to stop routine N-acetylcysteine treatment in young children in Denmark?

T2 - A review of 300 suspected paracetamol overdoses in children aged 0–6 years

AU - Gade, Christina

AU - Bøgevig, Søren

AU - Daoud, Alaa

AU - Mathiesen, Pernille R.

AU - Chrstensen, Mikkel B.

AU - Dalhoff, Kim P.

AU - Petersen, Tonny S.

N1 - Publisher Copyright: © 2021 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd

PY - 2022

Y1 - 2022

N2 - Aim: To evaluate the prevalence of potentially hepatoxic paracetamol ingestion and associated N-acetylcysteine treatment in young children suspected of paracetamol poisoning. Methods: A retrospective cohort study of children aged 0–6 years suspected of paracetamol poisoning with a related plasma-paracetamol measurement in the Capital Region of Denmark in the period 2010–2017. Data from the clinical laboratory system were linked to data from electronic patient records via the unique identification number given to all Danish residents. Results: Of 297 children included, suspected single paracetamol overdoses were present in 281 (95%). Sixty-nine per cent were treated with N-acetylcysteine, and the mean treatment period was 20.3 h (SD 20.8). A maximum of 6 (2%) of the children suspected of single overdose had plasma-paracetamol concentrations that exceeded the recommended treatment thresholds. No cases of severe hepatotoxicity were registered. Adverse events to N-acetylcysteine-treatment were registered in 3 (2%) children including one anaphylactoid reaction (0.5%). Conclusion: This study shows that initiating N-acetylcysteine as a ‘one size fit all’ treatment regimen in all children aged 0–6 years with a suspected single paracetamol overdose leads to substantial overtreatment. The data support that it is feasible to initiate N-acetylcysteine within 10 h based on an early plasma-paracetamol test.

AB - Aim: To evaluate the prevalence of potentially hepatoxic paracetamol ingestion and associated N-acetylcysteine treatment in young children suspected of paracetamol poisoning. Methods: A retrospective cohort study of children aged 0–6 years suspected of paracetamol poisoning with a related plasma-paracetamol measurement in the Capital Region of Denmark in the period 2010–2017. Data from the clinical laboratory system were linked to data from electronic patient records via the unique identification number given to all Danish residents. Results: Of 297 children included, suspected single paracetamol overdoses were present in 281 (95%). Sixty-nine per cent were treated with N-acetylcysteine, and the mean treatment period was 20.3 h (SD 20.8). A maximum of 6 (2%) of the children suspected of single overdose had plasma-paracetamol concentrations that exceeded the recommended treatment thresholds. No cases of severe hepatotoxicity were registered. Adverse events to N-acetylcysteine-treatment were registered in 3 (2%) children including one anaphylactoid reaction (0.5%). Conclusion: This study shows that initiating N-acetylcysteine as a ‘one size fit all’ treatment regimen in all children aged 0–6 years with a suspected single paracetamol overdose leads to substantial overtreatment. The data support that it is feasible to initiate N-acetylcysteine within 10 h based on an early plasma-paracetamol test.

U2 - 10.1111/apa.16185

DO - 10.1111/apa.16185

M3 - Journal article

C2 - 34773285

AN - SCOPUS:85121743075

VL - 111

SP - 667

EP - 674

JO - Acta Paediatrica

JF - Acta Paediatrica

SN - 0803-5253

IS - 3

ER -

ID: 290254367