Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt

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Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. / Melin, Beatrice S; Barnholtz-Sloan, Jill S; Wrensch, Margaret R.; Johansen, Christoffer; Il'yasova, Dora; Kinnersley, Ben; Ostrom, Quinn T; Labreche, Karim; Chen, Yanwen; Armstrong, Georgina N; Liu, Yanhong; Eckel-Passow, Jeanette; Decker, Paul A; Labussière, Marianne; Idbaih, Ahmed; Hoang-Xuan, Khe; Di Stefano, Anna-Luisa; Mokhtari, Karima; Delattre, Jean-Yves; Broderick, Peter; Galan, Pilar; Gousias, Konstantinos; Schramm, Johannes; Schoemaker, Minouk J; Fleming, Sarah J; Herms, Stefan; Heilmann-Heimbach, Stefanie; Nöthen, Markus M; Wichmann, Heinz-Erich; Schreiber, Stefan; Swerdlow, Anthony; Lathrop, Mark; Simon, Matthias; Sanson, Marc; Andersson, Ulrika; Rajaraman, Preetha; Chanock, Stephen; Linet, Martha S; Wang, Zhaoming; Yeager, Meredith; GliomaScan Consortium; Wiencke, John K; Hansen, Helen; Mccoy, Lucie S.; Rice, Terri; Kosel, Matthew L; Sicotte, Hugues; Amos, Christopher I; Bernstein, Jonine L; Davis, Faith G; Lachance, Dan.

I: Nature Genetics, Bind 49, Nr. 5, 2017, s. 789-794.

Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt

Harvard

Melin, BS, Barnholtz-Sloan, JS, Wrensch, MR, Johansen, C, Il'yasova, D, Kinnersley, B, Ostrom, QT, Labreche, K, Chen, Y, Armstrong, GN, Liu, Y, Eckel-Passow, J, Decker, PA, Labussière, M, Idbaih, A, Hoang-Xuan, K, Di Stefano, A-L, Mokhtari, K, Delattre, J-Y, Broderick, P, Galan, P, Gousias, K, Schramm, J, Schoemaker, MJ, Fleming, SJ, Herms, S, Heilmann-Heimbach, S, Nöthen, MM, Wichmann, H-E, Schreiber, S, Swerdlow, A, Lathrop, M, Simon, M, Sanson, M, Andersson, U, Rajaraman, P, Chanock, S, Linet, MS, Wang, Z, Yeager, M, GliomaScan Consortium, Wiencke, JK, Hansen, H, Mccoy, LS, Rice, T, Kosel, ML, Sicotte, H, Amos, CI, Bernstein, JL, Davis, FG & Lachance, D 2017, 'Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors', Nature Genetics, bind 49, nr. 5, s. 789-794. https://doi.org/10.1038/ng.3823

APA

Melin, B. S., Barnholtz-Sloan, J. S., Wrensch, M. R., Johansen, C., Il'yasova, D., Kinnersley, B., Ostrom, Q. T., Labreche, K., Chen, Y., Armstrong, G. N., Liu, Y., Eckel-Passow, J., Decker, P. A., Labussière, M., Idbaih, A., Hoang-Xuan, K., Di Stefano, A-L., Mokhtari, K., Delattre, J-Y., ... Lachance, D. (2017). Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. Nature Genetics, 49(5), 789-794. https://doi.org/10.1038/ng.3823

Vancouver

Melin BS, Barnholtz-Sloan JS, Wrensch MR, Johansen C, Il'yasova D, Kinnersley B o.a. Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. Nature Genetics. 2017;49(5):789-794. https://doi.org/10.1038/ng.3823

Author

Melin, Beatrice S ; Barnholtz-Sloan, Jill S ; Wrensch, Margaret R. ; Johansen, Christoffer ; Il'yasova, Dora ; Kinnersley, Ben ; Ostrom, Quinn T ; Labreche, Karim ; Chen, Yanwen ; Armstrong, Georgina N ; Liu, Yanhong ; Eckel-Passow, Jeanette ; Decker, Paul A ; Labussière, Marianne ; Idbaih, Ahmed ; Hoang-Xuan, Khe ; Di Stefano, Anna-Luisa ; Mokhtari, Karima ; Delattre, Jean-Yves ; Broderick, Peter ; Galan, Pilar ; Gousias, Konstantinos ; Schramm, Johannes ; Schoemaker, Minouk J ; Fleming, Sarah J ; Herms, Stefan ; Heilmann-Heimbach, Stefanie ; Nöthen, Markus M ; Wichmann, Heinz-Erich ; Schreiber, Stefan ; Swerdlow, Anthony ; Lathrop, Mark ; Simon, Matthias ; Sanson, Marc ; Andersson, Ulrika ; Rajaraman, Preetha ; Chanock, Stephen ; Linet, Martha S ; Wang, Zhaoming ; Yeager, Meredith ; GliomaScan Consortium ; Wiencke, John K ; Hansen, Helen ; Mccoy, Lucie S. ; Rice, Terri ; Kosel, Matthew L ; Sicotte, Hugues ; Amos, Christopher I ; Bernstein, Jonine L ; Davis, Faith G ; Lachance, Dan. / Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. I: Nature Genetics. 2017 ; Bind 49, Nr. 5. s. 789-794.

Bibtex

@article{c82247f296b74d1c88ae1e124818a173,
title = "Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors",
abstract = "Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10(-9), odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10(-10), OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10(-8), OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10(-11), OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10(-10), OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10(-9), OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10(-10), OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10(-10), OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10(-9), OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10(-8), OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10(-10), OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10(-11), OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10(-9), OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.",
keywords = "Journal Article",
author = "Melin, {Beatrice S} and Barnholtz-Sloan, {Jill S} and Wrensch, {Margaret R.} and Christoffer Johansen and Dora Il'yasova and Ben Kinnersley and Ostrom, {Quinn T} and Karim Labreche and Yanwen Chen and Armstrong, {Georgina N} and Yanhong Liu and Jeanette Eckel-Passow and Decker, {Paul A} and Marianne Labussi{\`e}re and Ahmed Idbaih and Khe Hoang-Xuan and {Di Stefano}, Anna-Luisa and Karima Mokhtari and Jean-Yves Delattre and Peter Broderick and Pilar Galan and Konstantinos Gousias and Johannes Schramm and Schoemaker, {Minouk J} and Fleming, {Sarah J} and Stefan Herms and Stefanie Heilmann-Heimbach and N{\"o}then, {Markus M} and Heinz-Erich Wichmann and Stefan Schreiber and Anthony Swerdlow and Mark Lathrop and Matthias Simon and Marc Sanson and Ulrika Andersson and Preetha Rajaraman and Stephen Chanock and Linet, {Martha S} and Zhaoming Wang and Meredith Yeager and {GliomaScan Consortium} and Wiencke, {John K} and Helen Hansen and Mccoy, {Lucie S.} and Terri Rice and Kosel, {Matthew L} and Hugues Sicotte and Amos, {Christopher I} and Bernstein, {Jonine L} and Davis, {Faith G} and Dan Lachance",
year = "2017",
doi = "10.1038/ng.3823",
language = "English",
volume = "49",
pages = "789--794",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "5",

}

RIS

TY - JOUR

T1 - Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

AU - Melin, Beatrice S

AU - Barnholtz-Sloan, Jill S

AU - Wrensch, Margaret R.

AU - Johansen, Christoffer

AU - Il'yasova, Dora

AU - Kinnersley, Ben

AU - Ostrom, Quinn T

AU - Labreche, Karim

AU - Chen, Yanwen

AU - Armstrong, Georgina N

AU - Liu, Yanhong

AU - Eckel-Passow, Jeanette

AU - Decker, Paul A

AU - Labussière, Marianne

AU - Idbaih, Ahmed

AU - Hoang-Xuan, Khe

AU - Di Stefano, Anna-Luisa

AU - Mokhtari, Karima

AU - Delattre, Jean-Yves

AU - Broderick, Peter

AU - Galan, Pilar

AU - Gousias, Konstantinos

AU - Schramm, Johannes

AU - Schoemaker, Minouk J

AU - Fleming, Sarah J

AU - Herms, Stefan

AU - Heilmann-Heimbach, Stefanie

AU - Nöthen, Markus M

AU - Wichmann, Heinz-Erich

AU - Schreiber, Stefan

AU - Swerdlow, Anthony

AU - Lathrop, Mark

AU - Simon, Matthias

AU - Sanson, Marc

AU - Andersson, Ulrika

AU - Rajaraman, Preetha

AU - Chanock, Stephen

AU - Linet, Martha S

AU - Wang, Zhaoming

AU - Yeager, Meredith

AU - GliomaScan Consortium

AU - Wiencke, John K

AU - Hansen, Helen

AU - Mccoy, Lucie S.

AU - Rice, Terri

AU - Kosel, Matthew L

AU - Sicotte, Hugues

AU - Amos, Christopher I

AU - Bernstein, Jonine L

AU - Davis, Faith G

AU - Lachance, Dan

PY - 2017

Y1 - 2017

N2 - Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10(-9), odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10(-10), OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10(-8), OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10(-11), OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10(-10), OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10(-9), OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10(-10), OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10(-10), OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10(-9), OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10(-8), OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10(-10), OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10(-11), OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10(-9), OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.

AB - Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10(-9), odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10(-10), OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10(-8), OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10(-11), OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10(-10), OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10(-9), OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10(-10), OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10(-10), OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10(-9), OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10(-8), OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10(-10), OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10(-11), OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10(-9), OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.

KW - Journal Article

U2 - 10.1038/ng.3823

DO - 10.1038/ng.3823

M3 - Letter

C2 - 28346443

VL - 49

SP - 789

EP - 794

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 5

ER -

ID: 179439700