Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

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Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. / Reveille, John D.; Sims, Anne Marie; Danoy, Patrick; Evans, David M.; Leo, Paul; Pointon, Jennifer J.; Jin, Rui; Zhou, Xiaodong; Bradbury, Linda A.; Appleton, Louise H.; Davis, John C.; Diekman, Laura; Doan, Tracey; Dowling, Alison; Duan, Ran; Duncan, Emma L.; Farrar, Claire; Hadler, Johanna; Harvey, David; Karaderi, Tugce; Mogg, Rebecca; Pomeroy, Emma; Pryce, Karena; Taylor, Jacqueline; Savage, Laurie; Deloukas, Panos; Kumanduri, Vasudev; Peltonen, Leena; Ring, Sue M.; Whittaker, Pamela; Glazov, Evgeny; Thomas, Gethin P.; Maksymowych, Walter P.; Inman, Robert D.; Ward, Michael M.; Stone, Millicent A.; Weisman, Michael H.; Wordsworth, B. Paul; Brown, Matthew A.

I: Nature Genetics, Bind 42, Nr. 2, 01.02.2010, s. 123-127.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Reveille, JD, Sims, AM, Danoy, P, Evans, DM, Leo, P, Pointon, JJ, Jin, R, Zhou, X, Bradbury, LA, Appleton, LH, Davis, JC, Diekman, L, Doan, T, Dowling, A, Duan, R, Duncan, EL, Farrar, C, Hadler, J, Harvey, D, Karaderi, T, Mogg, R, Pomeroy, E, Pryce, K, Taylor, J, Savage, L, Deloukas, P, Kumanduri, V, Peltonen, L, Ring, SM, Whittaker, P, Glazov, E, Thomas, GP, Maksymowych, WP, Inman, RD, Ward, MM, Stone, MA, Weisman, MH, Wordsworth, BP & Brown, MA 2010, 'Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci', Nature Genetics, bind 42, nr. 2, s. 123-127. https://doi.org/10.1038/ng.513

APA

Reveille, J. D., Sims, A. M., Danoy, P., Evans, D. M., Leo, P., Pointon, J. J., Jin, R., Zhou, X., Bradbury, L. A., Appleton, L. H., Davis, J. C., Diekman, L., Doan, T., Dowling, A., Duan, R., Duncan, E. L., Farrar, C., Hadler, J., Harvey, D., ... Brown, M. A. (2010). Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nature Genetics, 42(2), 123-127. https://doi.org/10.1038/ng.513

Vancouver

Reveille JD, Sims AM, Danoy P, Evans DM, Leo P, Pointon JJ o.a. Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nature Genetics. 2010 feb. 1;42(2):123-127. https://doi.org/10.1038/ng.513

Author

Reveille, John D. ; Sims, Anne Marie ; Danoy, Patrick ; Evans, David M. ; Leo, Paul ; Pointon, Jennifer J. ; Jin, Rui ; Zhou, Xiaodong ; Bradbury, Linda A. ; Appleton, Louise H. ; Davis, John C. ; Diekman, Laura ; Doan, Tracey ; Dowling, Alison ; Duan, Ran ; Duncan, Emma L. ; Farrar, Claire ; Hadler, Johanna ; Harvey, David ; Karaderi, Tugce ; Mogg, Rebecca ; Pomeroy, Emma ; Pryce, Karena ; Taylor, Jacqueline ; Savage, Laurie ; Deloukas, Panos ; Kumanduri, Vasudev ; Peltonen, Leena ; Ring, Sue M. ; Whittaker, Pamela ; Glazov, Evgeny ; Thomas, Gethin P. ; Maksymowych, Walter P. ; Inman, Robert D. ; Ward, Michael M. ; Stone, Millicent A. ; Weisman, Michael H. ; Wordsworth, B. Paul ; Brown, Matthew A. / Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. I: Nature Genetics. 2010 ; Bind 42, Nr. 2. s. 123-127.

Bibtex

@article{aaf7d6ef18e04a85b3cb160b00a6d615,

title = "Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci",

abstract = "To identify susceptibility loci for ankylosing spondylitis, we undertook a genome-wide association study in 2,053 unrelated ankylosing spondylitis cases among people of European descent and 5,140 ethnically matched controls, with replication in an independent cohort of 898 ankylosing spondylitis cases and 1,518 controls. Cases were genotyped with Illumina HumHap370 genotyping chips. In addition to strong association with the major histocompatibility complex (MHC; P 10 800), we found association with SNPs in two gene deserts at 2p15 (rs10865331; combined P = 1.9 × 10 19) and 21q22 (rs2242944; P = 8.3 × 10 20), as well as in the genes ANTXR2 (rs4333130; P = 9.3 × 10 8) and IL1R2 (rs2310173; P = 4.8 × 10 7). We also replicated previously reported associations at IL23R (rs11209026; P = 9.1 × 10 14) and ERAP1 (rs27434; P = 5.3 × 10 12). This study reports four genetic loci associated with ankylosing spondylitis risk and identifies a major role for the interleukin (IL)-23 and IL-1 cytokine pathways in disease susceptibility.",

author = "Reveille, {John D.} and Sims, {Anne Marie} and Patrick Danoy and Evans, {David M.} and Paul Leo and Pointon, {Jennifer J.} and Rui Jin and Xiaodong Zhou and Bradbury, {Linda A.} and Appleton, {Louise H.} and Davis, {John C.} and Laura Diekman and Tracey Doan and Alison Dowling and Ran Duan and Duncan, {Emma L.} and Claire Farrar and Johanna Hadler and David Harvey and Tugce Karaderi and Rebecca Mogg and Emma Pomeroy and Karena Pryce and Jacqueline Taylor and Laurie Savage and Panos Deloukas and Vasudev Kumanduri and Leena Peltonen and Ring, {Sue M.} and Pamela Whittaker and Evgeny Glazov and Thomas, {Gethin P.} and Maksymowych, {Walter P.} and Inman, {Robert D.} and Ward, {Michael M.} and Stone, {Millicent A.} and Weisman, {Michael H.} and Wordsworth, {B. Paul} and Brown, {Matthew A.}",

year = "2010",

month = feb,

day = "1",

doi = "10.1038/ng.513",

language = "English",

volume = "42",

pages = "123--127",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "nature publishing group",

number = "2",

}

RIS

TY - JOUR

T1 - Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

AU - Reveille, John D.

AU - Sims, Anne Marie

AU - Danoy, Patrick

AU - Evans, David M.

AU - Leo, Paul

AU - Pointon, Jennifer J.

AU - Jin, Rui

AU - Zhou, Xiaodong

AU - Bradbury, Linda A.

AU - Appleton, Louise H.

AU - Davis, John C.

AU - Diekman, Laura

AU - Doan, Tracey

AU - Dowling, Alison

AU - Duan, Ran

AU - Duncan, Emma L.

AU - Farrar, Claire

AU - Hadler, Johanna

AU - Harvey, David

AU - Karaderi, Tugce

AU - Mogg, Rebecca

AU - Pomeroy, Emma

AU - Pryce, Karena

AU - Taylor, Jacqueline

AU - Savage, Laurie

AU - Deloukas, Panos

AU - Kumanduri, Vasudev

AU - Peltonen, Leena

AU - Ring, Sue M.

AU - Whittaker, Pamela

AU - Glazov, Evgeny

AU - Thomas, Gethin P.

AU - Maksymowych, Walter P.

AU - Inman, Robert D.

AU - Ward, Michael M.

AU - Stone, Millicent A.

AU - Weisman, Michael H.

AU - Wordsworth, B. Paul

AU - Brown, Matthew A.

PY - 2010/2/1

Y1 - 2010/2/1

N2 - To identify susceptibility loci for ankylosing spondylitis, we undertook a genome-wide association study in 2,053 unrelated ankylosing spondylitis cases among people of European descent and 5,140 ethnically matched controls, with replication in an independent cohort of 898 ankylosing spondylitis cases and 1,518 controls. Cases were genotyped with Illumina HumHap370 genotyping chips. In addition to strong association with the major histocompatibility complex (MHC; P 10 800), we found association with SNPs in two gene deserts at 2p15 (rs10865331; combined P = 1.9 × 10 19) and 21q22 (rs2242944; P = 8.3 × 10 20), as well as in the genes ANTXR2 (rs4333130; P = 9.3 × 10 8) and IL1R2 (rs2310173; P = 4.8 × 10 7). We also replicated previously reported associations at IL23R (rs11209026; P = 9.1 × 10 14) and ERAP1 (rs27434; P = 5.3 × 10 12). This study reports four genetic loci associated with ankylosing spondylitis risk and identifies a major role for the interleukin (IL)-23 and IL-1 cytokine pathways in disease susceptibility.

AB - To identify susceptibility loci for ankylosing spondylitis, we undertook a genome-wide association study in 2,053 unrelated ankylosing spondylitis cases among people of European descent and 5,140 ethnically matched controls, with replication in an independent cohort of 898 ankylosing spondylitis cases and 1,518 controls. Cases were genotyped with Illumina HumHap370 genotyping chips. In addition to strong association with the major histocompatibility complex (MHC; P 10 800), we found association with SNPs in two gene deserts at 2p15 (rs10865331; combined P = 1.9 × 10 19) and 21q22 (rs2242944; P = 8.3 × 10 20), as well as in the genes ANTXR2 (rs4333130; P = 9.3 × 10 8) and IL1R2 (rs2310173; P = 4.8 × 10 7). We also replicated previously reported associations at IL23R (rs11209026; P = 9.1 × 10 14) and ERAP1 (rs27434; P = 5.3 × 10 12). This study reports four genetic loci associated with ankylosing spondylitis risk and identifies a major role for the interleukin (IL)-23 and IL-1 cytokine pathways in disease susceptibility.

UR - http://www.scopus.com/inward/record.url?scp=75749085686&partnerID=8YFLogxK

U2 - 10.1038/ng.513

DO - 10.1038/ng.513

M3 - Journal article

C2 - 20062062

AN - SCOPUS:75749085686

VL - 42

SP - 123

EP - 127

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 2

ER -

ID: 226397315