Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt

Standard

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population. / Robinson, Elise B; St Pourcain, Beate; Anttila, Verneri; Kosmicki, Jack A; Bulik-Sullivan, Brendan; Grove, Jakob; Maller, Julian; Samocha, Kaitlin E; Sanders, Jan-Stephan F; Ripke, Stephan; Martin, Joanna; Hollegaard, Mads V; Werge, Thomas; Hougaard, David M.; Neale, Benjamin M; Evans, David M; Skuse, David; Mortensen, Preben Bo; Børglum, Anders D; Ronald, Angelica; Smith, George Davey; Daly, Mark J; iPSYCH-SSI-Broad Autism Group.

I: Nature Genetics, Bind 48, Nr. 5, 2016, s. 552-5.

Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt

Harvard

Robinson, EB, St Pourcain, B, Anttila, V, Kosmicki, JA, Bulik-Sullivan, B, Grove, J, Maller, J, Samocha, KE, Sanders, J-SF, Ripke, S, Martin, J, Hollegaard, MV, Werge, T, Hougaard, DM, Neale, BM, Evans, DM, Skuse, D, Mortensen, PB, Børglum, AD, Ronald, A, Smith, GD, Daly, MJ & iPSYCH-SSI-Broad Autism Group 2016, 'Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population', Nature Genetics, bind 48, nr. 5, s. 552-5. https://doi.org/10.1038/ng.3529

APA

Robinson, E. B., St Pourcain, B., Anttila, V., Kosmicki, J. A., Bulik-Sullivan, B., Grove, J., Maller, J., Samocha, K. E., Sanders, J-S. F., Ripke, S., Martin, J., Hollegaard, M. V., Werge, T., Hougaard, D. M., Neale, B. M., Evans, D. M., Skuse, D., Mortensen, P. B., Børglum, A. D., ... iPSYCH-SSI-Broad Autism Group (2016). Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population. Nature Genetics, 48(5), 552-5. https://doi.org/10.1038/ng.3529

Vancouver

Robinson EB, St Pourcain B, Anttila V, Kosmicki JA, Bulik-Sullivan B, Grove J o.a. Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population. Nature Genetics. 2016;48(5):552-5. https://doi.org/10.1038/ng.3529

Author

Robinson, Elise B ; St Pourcain, Beate ; Anttila, Verneri ; Kosmicki, Jack A ; Bulik-Sullivan, Brendan ; Grove, Jakob ; Maller, Julian ; Samocha, Kaitlin E ; Sanders, Jan-Stephan F ; Ripke, Stephan ; Martin, Joanna ; Hollegaard, Mads V ; Werge, Thomas ; Hougaard, David M. ; Neale, Benjamin M ; Evans, David M ; Skuse, David ; Mortensen, Preben Bo ; Børglum, Anders D ; Ronald, Angelica ; Smith, George Davey ; Daly, Mark J ; iPSYCH-SSI-Broad Autism Group. / Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population. I: Nature Genetics. 2016 ; Bind 48, Nr. 5. s. 552-5.

Bibtex

@article{109fd895c03f42f48ff9c8752faf6f5c,
title = "Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population",
abstract = "Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the general population, but the effects of this risk are unclear in people not ascertained for neuropsychiatric symptoms. Using several large ASD consortium and population-based resources (total n > 38,000), we find genome-wide genetic links between ASDs and typical variation in social behavior and adaptive functioning. This finding is evidenced through both LD score correlation and de novo variant analysis, indicating that multiple types of genetic risk for ASDs influence a continuum of behavioral and developmental traits, the severe tail of which can result in diagnosis with an ASD or other neuropsychiatric disorder. A continuum model should inform the design and interpretation of studies of neuropsychiatric disease biology.",
keywords = "Journal Article",
author = "Robinson, {Elise B} and {St Pourcain}, Beate and Verneri Anttila and Kosmicki, {Jack A} and Brendan Bulik-Sullivan and Jakob Grove and Julian Maller and Samocha, {Kaitlin E} and Sanders, {Jan-Stephan F} and Stephan Ripke and Joanna Martin and Hollegaard, {Mads V} and Thomas Werge and Hougaard, {David M.} and Neale, {Benjamin M} and Evans, {David M} and David Skuse and Mortensen, {Preben Bo} and B{\o}rglum, {Anders D} and Angelica Ronald and Smith, {George Davey} and Daly, {Mark J} and {iPSYCH-SSI-Broad Autism Group}",
year = "2016",
doi = "10.1038/ng.3529",
language = "English",
volume = "48",
pages = "552--5",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "5",

}

RIS

TY - JOUR

T1 - Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

AU - Robinson, Elise B

AU - St Pourcain, Beate

AU - Anttila, Verneri

AU - Kosmicki, Jack A

AU - Bulik-Sullivan, Brendan

AU - Grove, Jakob

AU - Maller, Julian

AU - Samocha, Kaitlin E

AU - Sanders, Jan-Stephan F

AU - Ripke, Stephan

AU - Martin, Joanna

AU - Hollegaard, Mads V

AU - Werge, Thomas

AU - Hougaard, David M.

AU - Neale, Benjamin M

AU - Evans, David M

AU - Skuse, David

AU - Mortensen, Preben Bo

AU - Børglum, Anders D

AU - Ronald, Angelica

AU - Smith, George Davey

AU - Daly, Mark J

AU - iPSYCH-SSI-Broad Autism Group

PY - 2016

Y1 - 2016

N2 - Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the general population, but the effects of this risk are unclear in people not ascertained for neuropsychiatric symptoms. Using several large ASD consortium and population-based resources (total n > 38,000), we find genome-wide genetic links between ASDs and typical variation in social behavior and adaptive functioning. This finding is evidenced through both LD score correlation and de novo variant analysis, indicating that multiple types of genetic risk for ASDs influence a continuum of behavioral and developmental traits, the severe tail of which can result in diagnosis with an ASD or other neuropsychiatric disorder. A continuum model should inform the design and interpretation of studies of neuropsychiatric disease biology.

AB - Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the general population, but the effects of this risk are unclear in people not ascertained for neuropsychiatric symptoms. Using several large ASD consortium and population-based resources (total n > 38,000), we find genome-wide genetic links between ASDs and typical variation in social behavior and adaptive functioning. This finding is evidenced through both LD score correlation and de novo variant analysis, indicating that multiple types of genetic risk for ASDs influence a continuum of behavioral and developmental traits, the severe tail of which can result in diagnosis with an ASD or other neuropsychiatric disorder. A continuum model should inform the design and interpretation of studies of neuropsychiatric disease biology.

KW - Journal Article

U2 - 10.1038/ng.3529

DO - 10.1038/ng.3529

M3 - Letter

C2 - 26998691

VL - 48

SP - 552

EP - 555

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 5

ER -

ID: 177068172