Genetic Determinants of Weight Loss After Bariatric Surgery
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Genetic Determinants of Weight Loss After Bariatric Surgery. / Aasbrenn, Martin; Schnurr, Theresia Maria; Have, Christian Theil; Svendstrup, Mathilde; Hansen, Dorte Lindqvist; Worm, Dorte; Balslev-Harder, Marie; Hollensted, Mette; Grarup, Niels; Burgdorf, Kristoffer Sølvsten; Vestergaard, Henrik; Pedersen, Oluf; Sørensen, Thorkild I. A.; Fenger, Mogens; Madsbad, Sten; Hansen, Torben.
I: Obesity Surgery, Bind 29, Nr. 8, 2019, s. 2554-2561.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Genetic Determinants of Weight Loss After Bariatric Surgery
AU - Aasbrenn, Martin
AU - Schnurr, Theresia Maria
AU - Have, Christian Theil
AU - Svendstrup, Mathilde
AU - Hansen, Dorte Lindqvist
AU - Worm, Dorte
AU - Balslev-Harder, Marie
AU - Hollensted, Mette
AU - Grarup, Niels
AU - Burgdorf, Kristoffer Sølvsten
AU - Vestergaard, Henrik
AU - Pedersen, Oluf
AU - Sørensen, Thorkild I. A.
AU - Fenger, Mogens
AU - Madsbad, Sten
AU - Hansen, Torben
PY - 2019
Y1 - 2019
N2 - BACKGROUND: The weight loss after bariatric surgery shows considerable individual variation. Twin studies of response to dietary interventions and studies of bariatric surgery patients suggest that genetic differences may play a role. This study aimed to examine the effect of three genetic risk scores on the inter-individual variation in excess body mass index loss (EBMIL) after Roux-en-Y gastric bypass. Furthermore, we searched among known adiposity-related single nucleotide polymorphisms (SNPs) for genetic determinants of the inter-individual variation in EBMIL.METHODS: Patients with morbid obesity underwent Roux-en-Y gastric bypass and were genotyped (n = 577). Two genetic risk scores for weight loss after bariatric surgery and a genetic risk score for body mass index were calculated. Associations between the genetic risk scores and EBMIL were evaluated. Lasso regression was performed on 126 SNPs known to be associated with adiposity.RESULTS: The average EBMIL was 76.9% (range 21.7-149.2%). EBMIL was 81.1% (SD 20.6) and 73.9% (SD 21.7) in the high and low tertile groups of a genetic risk score for weight loss. Patients with a low genetic risk score for body mass index (in the lowest 5% percentile) had an EBMIL of 68.8% (SD 20.6, p = 0.018). Thirteen adiposity-related SNPs were identified to associate with EBMIL through lasso regression.DISCUSSION: A genetic risk score was associated with EBMIL after bariatric surgery, but may not yet be applicable to clinical practice. Patients genetically predisposed to low body mass index had lower weight loss after bariatric surgery.
AB - BACKGROUND: The weight loss after bariatric surgery shows considerable individual variation. Twin studies of response to dietary interventions and studies of bariatric surgery patients suggest that genetic differences may play a role. This study aimed to examine the effect of three genetic risk scores on the inter-individual variation in excess body mass index loss (EBMIL) after Roux-en-Y gastric bypass. Furthermore, we searched among known adiposity-related single nucleotide polymorphisms (SNPs) for genetic determinants of the inter-individual variation in EBMIL.METHODS: Patients with morbid obesity underwent Roux-en-Y gastric bypass and were genotyped (n = 577). Two genetic risk scores for weight loss after bariatric surgery and a genetic risk score for body mass index were calculated. Associations between the genetic risk scores and EBMIL were evaluated. Lasso regression was performed on 126 SNPs known to be associated with adiposity.RESULTS: The average EBMIL was 76.9% (range 21.7-149.2%). EBMIL was 81.1% (SD 20.6) and 73.9% (SD 21.7) in the high and low tertile groups of a genetic risk score for weight loss. Patients with a low genetic risk score for body mass index (in the lowest 5% percentile) had an EBMIL of 68.8% (SD 20.6, p = 0.018). Thirteen adiposity-related SNPs were identified to associate with EBMIL through lasso regression.DISCUSSION: A genetic risk score was associated with EBMIL after bariatric surgery, but may not yet be applicable to clinical practice. Patients genetically predisposed to low body mass index had lower weight loss after bariatric surgery.
U2 - 10.1007/s11695-019-03878-5
DO - 10.1007/s11695-019-03878-5
M3 - Journal article
C2 - 31001758
VL - 29
SP - 2554
EP - 2561
JO - Obesity Surgery
JF - Obesity Surgery
SN - 0960-8923
IS - 8
ER -
ID: 222319712