Gender- and age-specific rates of heart failure and other adverse cardiovascular outcomes in systemic sclerosis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Gender- and age-specific rates of heart failure and other adverse cardiovascular outcomes in systemic sclerosis. / Sun, Guoli; Yafasova, Adelina; Andersson, Charlotte; McMurray, John J.; Jhund, Pardeep S.; Docherty, Kieran F.; Faurschou, Mikkel; Nielsen, Christoffer T.; Schou, Morten; Gislason, Gunnar H.; Torp-Pedersen, Christian; Fosbøl, Emil L.; Køber, Lars; Butt, Jawad H.
I: Rheumatology, Bind 61, Nr. 11, 2022, s. 4374–4383.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Gender- and age-specific rates of heart failure and other adverse cardiovascular outcomes in systemic sclerosis
AU - Sun, Guoli
AU - Yafasova, Adelina
AU - Andersson, Charlotte
AU - McMurray, John J.
AU - Jhund, Pardeep S.
AU - Docherty, Kieran F.
AU - Faurschou, Mikkel
AU - Nielsen, Christoffer T.
AU - Schou, Morten
AU - Gislason, Gunnar H.
AU - Torp-Pedersen, Christian
AU - Fosbøl, Emil L.
AU - Køber, Lars
AU - Butt, Jawad H.
PY - 2022
Y1 - 2022
N2 - Objective To investigate the long-term rates of heart failure (HF) and other adverse cardiovascular outcomes, including arrhythmias, myocardial infarction, ischaemic stroke, venous thromboembolism, pulmonary hypertension and pericarditis, in SSc patients according to gender and age. Methods Using Danish nationwide registries, SSc patients (diagnosed from 1996 to 2018) were matched with four controls from the background population by gender, age and comorbidities. Cox regression was used to compare the rates of cardiovascular outcomes between SSc patients and controls and the rate of mortality between SSc patients developing HF and HF patients without SSc, according to gender and age (above/below median). Results In total, 1569 SSc patients were matched with 6276 non-SSc controls (median age 55 years, 80.4% women, median follow-up 7.3 years). SSc had a higher rate of HF in both women [HR 2.99 (95% CI 2.18, 4.09)] and men [HR 3.01 (1.83, 4.95)] (P-interaction = 0.88), with similar trends for other cardiovascular outcomes. SSc had a higher rate of HF in patients = 55 years [HR 2.74 (1.98, 3.78)] (P-interaction = 0.22), with similar trends for other cardiovascular outcomes. SSc patients with new-onset HF had a higher rate of mortality than HF patients without a history of SSc, irrespective of gender (P-interaction = 0.53) and age (P-interaction = 0.43). Conclusions SSc was associated with higher rates of HF and other cardiovascular outcomes than matched controls, irrespective of gender and age. Among patients with new-onset HF, a history of SSc was associated with higher mortality.
AB - Objective To investigate the long-term rates of heart failure (HF) and other adverse cardiovascular outcomes, including arrhythmias, myocardial infarction, ischaemic stroke, venous thromboembolism, pulmonary hypertension and pericarditis, in SSc patients according to gender and age. Methods Using Danish nationwide registries, SSc patients (diagnosed from 1996 to 2018) were matched with four controls from the background population by gender, age and comorbidities. Cox regression was used to compare the rates of cardiovascular outcomes between SSc patients and controls and the rate of mortality between SSc patients developing HF and HF patients without SSc, according to gender and age (above/below median). Results In total, 1569 SSc patients were matched with 6276 non-SSc controls (median age 55 years, 80.4% women, median follow-up 7.3 years). SSc had a higher rate of HF in both women [HR 2.99 (95% CI 2.18, 4.09)] and men [HR 3.01 (1.83, 4.95)] (P-interaction = 0.88), with similar trends for other cardiovascular outcomes. SSc had a higher rate of HF in patients = 55 years [HR 2.74 (1.98, 3.78)] (P-interaction = 0.22), with similar trends for other cardiovascular outcomes. SSc patients with new-onset HF had a higher rate of mortality than HF patients without a history of SSc, irrespective of gender (P-interaction = 0.53) and age (P-interaction = 0.43). Conclusions SSc was associated with higher rates of HF and other cardiovascular outcomes than matched controls, irrespective of gender and age. Among patients with new-onset HF, a history of SSc was associated with higher mortality.
KW - systemic sclerosis
KW - heart failure
KW - gender
KW - age
KW - PULMONARY ARTERIAL-HYPERTENSION
KW - ACUTE MYOCARDIAL-INFARCTION
KW - RISK
KW - SURVIVAL
KW - DISEASE
KW - MORTALITY
KW - IMPACT
KW - ONSET
KW - OLDER
KW - SEX
U2 - 10.1093/rheumatology/keac072
DO - 10.1093/rheumatology/keac072
M3 - Journal article
C2 - 35136973
VL - 61
SP - 4374
EP - 4383
JO - Rheumatology
JF - Rheumatology
SN - 1462-0324
IS - 11
ER -
ID: 299390478