Familial clustering and subsequent incidence of atrial fibrillation among first-degree relatives in Denmark

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Standard

Familial clustering and subsequent incidence of atrial fibrillation among first-degree relatives in Denmark. / Gundlund, Anna; Christiansen, Mia N; Hansen, Morten Lock; Olesen, Jonas Bjerring; Zahir, Deewa; Køber, Lars; Gislason, Gunnar H; Piccini, Jonathan P; Peterson, Eric D; Torp-Pedersen, Christian; Fosbøl, Emil Loldrup.

I: Europace, Bind 18, Nr. 5, 2016, s. 658-64.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Gundlund, A, Christiansen, MN, Hansen, ML, Olesen, JB, Zahir, D, Køber, L, Gislason, GH, Piccini, JP, Peterson, ED, Torp-Pedersen, C & Fosbøl, EL 2016, 'Familial clustering and subsequent incidence of atrial fibrillation among first-degree relatives in Denmark', Europace, bind 18, nr. 5, s. 658-64. https://doi.org/10.1093/europace/euv274

APA

Gundlund, A., Christiansen, M. N., Hansen, M. L., Olesen, J. B., Zahir, D., Køber, L., Gislason, G. H., Piccini, J. P., Peterson, E. D., Torp-Pedersen, C., & Fosbøl, E. L. (2016). Familial clustering and subsequent incidence of atrial fibrillation among first-degree relatives in Denmark. Europace, 18(5), 658-64. https://doi.org/10.1093/europace/euv274

Vancouver

Gundlund A, Christiansen MN, Hansen ML, Olesen JB, Zahir D, Køber L o.a. Familial clustering and subsequent incidence of atrial fibrillation among first-degree relatives in Denmark. Europace. 2016;18(5):658-64. https://doi.org/10.1093/europace/euv274

Author

Gundlund, Anna ; Christiansen, Mia N ; Hansen, Morten Lock ; Olesen, Jonas Bjerring ; Zahir, Deewa ; Køber, Lars ; Gislason, Gunnar H ; Piccini, Jonathan P ; Peterson, Eric D ; Torp-Pedersen, Christian ; Fosbøl, Emil Loldrup. / Familial clustering and subsequent incidence of atrial fibrillation among first-degree relatives in Denmark. I: Europace. 2016 ; Bind 18, Nr. 5. s. 658-64.

Bibtex

@article{3c049fe374844f9d88790eb2bd7d3ca5,

title = "Familial clustering and subsequent incidence of atrial fibrillation among first-degree relatives in Denmark",

abstract = "AIMS: Atrial fibrillation (AF) is associated with increased morbidity and mortality. Determination and quantification of familial risk may help identify high-risk patients.METHODS AND RESULTS: Using Danish nationwide registry data (1978-2012), we identified all first-time AF patients (probands) in Denmark. Relatives to these probands were grouped according to proband-relation: offspring from either maternal or paternal proband, and siblings to proband. Age-specific incidence of AF for these three groups of relatives and for the general Danish population was estimated. Using the general population as reference, we calculated adjusted rate ratios (RRs) of AF in the three groups of relatives. We identified 67 310, 103 822, and 11 800 AF probands who were mothers (median age 74 years, IQR 66-81), fathers (70 years, IQR 62-78), and siblings (46 years, IQR 38-52), respectively. Among those, 133 516, 221 774, and 21 448 offspring from a maternal proband, offspring from a paternal proband, and siblings, respectively, were screened for incident AF. This was recorded in 2536 (1.9%), 2906 (1.3%), and 292 (1.4%) relatives, respectively. Compared with the general Danish population, the adjusted RRs for incident AF were 3.37 [95% confidence interval (CI) 3.21-3.53] for offspring from maternal probands, 2.81 (95% CI 2.69-2.93) for offspring from paternal probands, and 5.20 (95% CI 4.61-5.85) for siblings to sibling probands. Subgroup analyses showed increased RRs with younger aged probands.CONCLUSION: Familial AF was associated with an increased RR of AF in first-degree relatives compared with the general Danish population. This suggests that familial AF is a major risk factor for developing AF in relatives.",

keywords = "Journal Article",

author = "Anna Gundlund and Christiansen, {Mia N} and Hansen, {Morten Lock} and Olesen, {Jonas Bjerring} and Deewa Zahir and Lars K{\o}ber and Gislason, {Gunnar H} and Piccini, {Jonathan P} and Peterson, {Eric D} and Christian Torp-Pedersen and Fosb{\o}l, {Emil Loldrup}",

year = "2016",

doi = "10.1093/europace/euv274",

language = "English",

volume = "18",

pages = "658--64",

journal = "Europace",

issn = "1099-5129",

publisher = "Oxford University Press",

number = "5",

}

RIS

TY - JOUR

T1 - Familial clustering and subsequent incidence of atrial fibrillation among first-degree relatives in Denmark

AU - Gundlund, Anna

AU - Christiansen, Mia N

AU - Hansen, Morten Lock

AU - Olesen, Jonas Bjerring

AU - Zahir, Deewa

AU - Køber, Lars

AU - Gislason, Gunnar H

AU - Piccini, Jonathan P

AU - Peterson, Eric D

AU - Torp-Pedersen, Christian

AU - Fosbøl, Emil Loldrup

PY - 2016

Y1 - 2016

N2 - AIMS: Atrial fibrillation (AF) is associated with increased morbidity and mortality. Determination and quantification of familial risk may help identify high-risk patients.METHODS AND RESULTS: Using Danish nationwide registry data (1978-2012), we identified all first-time AF patients (probands) in Denmark. Relatives to these probands were grouped according to proband-relation: offspring from either maternal or paternal proband, and siblings to proband. Age-specific incidence of AF for these three groups of relatives and for the general Danish population was estimated. Using the general population as reference, we calculated adjusted rate ratios (RRs) of AF in the three groups of relatives. We identified 67 310, 103 822, and 11 800 AF probands who were mothers (median age 74 years, IQR 66-81), fathers (70 years, IQR 62-78), and siblings (46 years, IQR 38-52), respectively. Among those, 133 516, 221 774, and 21 448 offspring from a maternal proband, offspring from a paternal proband, and siblings, respectively, were screened for incident AF. This was recorded in 2536 (1.9%), 2906 (1.3%), and 292 (1.4%) relatives, respectively. Compared with the general Danish population, the adjusted RRs for incident AF were 3.37 [95% confidence interval (CI) 3.21-3.53] for offspring from maternal probands, 2.81 (95% CI 2.69-2.93) for offspring from paternal probands, and 5.20 (95% CI 4.61-5.85) for siblings to sibling probands. Subgroup analyses showed increased RRs with younger aged probands.CONCLUSION: Familial AF was associated with an increased RR of AF in first-degree relatives compared with the general Danish population. This suggests that familial AF is a major risk factor for developing AF in relatives.

AB - AIMS: Atrial fibrillation (AF) is associated with increased morbidity and mortality. Determination and quantification of familial risk may help identify high-risk patients.METHODS AND RESULTS: Using Danish nationwide registry data (1978-2012), we identified all first-time AF patients (probands) in Denmark. Relatives to these probands were grouped according to proband-relation: offspring from either maternal or paternal proband, and siblings to proband. Age-specific incidence of AF for these three groups of relatives and for the general Danish population was estimated. Using the general population as reference, we calculated adjusted rate ratios (RRs) of AF in the three groups of relatives. We identified 67 310, 103 822, and 11 800 AF probands who were mothers (median age 74 years, IQR 66-81), fathers (70 years, IQR 62-78), and siblings (46 years, IQR 38-52), respectively. Among those, 133 516, 221 774, and 21 448 offspring from a maternal proband, offspring from a paternal proband, and siblings, respectively, were screened for incident AF. This was recorded in 2536 (1.9%), 2906 (1.3%), and 292 (1.4%) relatives, respectively. Compared with the general Danish population, the adjusted RRs for incident AF were 3.37 [95% confidence interval (CI) 3.21-3.53] for offspring from maternal probands, 2.81 (95% CI 2.69-2.93) for offspring from paternal probands, and 5.20 (95% CI 4.61-5.85) for siblings to sibling probands. Subgroup analyses showed increased RRs with younger aged probands.CONCLUSION: Familial AF was associated with an increased RR of AF in first-degree relatives compared with the general Danish population. This suggests that familial AF is a major risk factor for developing AF in relatives.

KW - Journal Article

U2 - 10.1093/europace/euv274

DO - 10.1093/europace/euv274

M3 - Journal article

C2 - 26559919

VL - 18

SP - 658

EP - 664

JO - Europace

JF - Europace

SN - 1099-5129

IS - 5

ER -

ID: 164465285