Exaggerated natriuresis and lithium clearance in spontaneously hypertensive rats.
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Exaggerated natriuresis and lithium clearance in spontaneously hypertensive rats. / Holstein-Rathlou, N H; Kanters, J K; Leyssac, P P.
I: Journal of Hypertension, Bind 6, Nr. 11, 1988, s. 889-95.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Exaggerated natriuresis and lithium clearance in spontaneously hypertensive rats.
AU - Holstein-Rathlou, N H
AU - Kanters, J K
AU - Leyssac, P P
N1 - Keywords: Animals; Hypertension; Inulin; Kidney Tubules, Proximal; Lithium; Male; Natriuresis; Rats; Rats, Inbred SHR; Rats, Inbred WKY
PY - 1988
Y1 - 1988
N2 - Since hypertension is associated with changes in the handling of various cations (including sodium and lithium) across the cell membrane, the present study investigated the validity of the lithium clearance method in hypertension by comparing two measures of proximal reabsorption. Thus, fractional lithium excretion and transit time (TT)-occlusion time (OT; e-TT/T) were determined successively in the same spontaneously hypertensive rat (SHR, Okamoto strain). The rats were examined both before and after an acute saline load. The results show that the lithium clearance method can be used for the determination of proximal reabsorption in SHR. Utilizing the lithium clearance method, the changes in renal sodium handling underlying the exaggerated natriuresis were investigated in unanaesthetized catheterized rats. It was found that the exaggerated natriuresis was associated with an increased output from the proximal tubule, whereas no difference in distal sodium handling could be detected between SHR and normotensive Wistar-Kyoto rats (WKY).
AB - Since hypertension is associated with changes in the handling of various cations (including sodium and lithium) across the cell membrane, the present study investigated the validity of the lithium clearance method in hypertension by comparing two measures of proximal reabsorption. Thus, fractional lithium excretion and transit time (TT)-occlusion time (OT; e-TT/T) were determined successively in the same spontaneously hypertensive rat (SHR, Okamoto strain). The rats were examined both before and after an acute saline load. The results show that the lithium clearance method can be used for the determination of proximal reabsorption in SHR. Utilizing the lithium clearance method, the changes in renal sodium handling underlying the exaggerated natriuresis were investigated in unanaesthetized catheterized rats. It was found that the exaggerated natriuresis was associated with an increased output from the proximal tubule, whereas no difference in distal sodium handling could be detected between SHR and normotensive Wistar-Kyoto rats (WKY).
M3 - Journal article
C2 - 3235836
VL - 6
SP - 889
EP - 895
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 11
ER -
ID: 8440105