Evidence for a mediator cycle at the initiation of transcription
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Free and elongating (DNA-bound) forms of RNA polymerase II were separated from yeast. Most cellular polymerase II was found in the elongating fraction, which contained all enzyme phosphorylated on the C-terminal domain and none of the 15-subunit mediator of transcriptional regulation. These and other findings suggest that mediator enters and leaves initiation complexes during every round of transcription, in a process that may be coupled to C- terminal domain phosphorylation.
Originalsprog | Engelsk |
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Tidsskrift | Proceedings of the National Academy of Sciences of the United States of America |
Vol/bind | 94 |
Udgave nummer | 12 |
Sider (fra-til) | 6075-6078 |
Antal sider | 4 |
ISSN | 0027-8424 |
DOI | |
Status | Udgivet - 10 jun. 1997 |
Eksternt udgivet | Ja |
ID: 331574765