Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. / Lee, S Hong; DeCandia, Teresa R; Ripke, Stephan; Yang, Jian; Sullivan, Patrick F; Goddard, Michael E; Keller, Matthew C; Visscher, Peter M; Wray, Naomi R; Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC-SCZ); Hansen, Thomas Folkmann; Ingason, Andrés; Olsen, Line; Rasmussen, Henrik Berg; Werge, Thomas Mears.
I: Nature Genetics, Bind 44, Nr. 3, 2012, s. 247-50.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
AU - Lee, S Hong
AU - DeCandia, Teresa R
AU - Ripke, Stephan
AU - Yang, Jian
AU - Sullivan, Patrick F
AU - Goddard, Michael E
AU - Keller, Matthew C
AU - Visscher, Peter M
AU - Wray, Naomi R
AU - Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC-SCZ)
AU - Hansen, Thomas Folkmann
AU - Ingason, Andrés
AU - Olsen, Line
AU - Rasmussen, Henrik Berg
AU - Werge, Thomas Mears
PY - 2012
Y1 - 2012
N2 - Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC-SCZ), we estimate that 23% (s.e. = 1%) of variation in liability to schizophrenia is captured by SNPs. We show that a substantial proportion of this variation must be the result of common causal variants, that the variance explained by each chromosome is linearly related to its length (r = 0.89, P = 2.6 × 10(-8)), that the genetic basis of schizophrenia is the same in males and females, and that a disproportionate proportion of variation is attributable to a set of 2,725 genes expressed in the central nervous system (CNS; P = 7.6 × 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases.
AB - Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC-SCZ), we estimate that 23% (s.e. = 1%) of variation in liability to schizophrenia is captured by SNPs. We show that a substantial proportion of this variation must be the result of common causal variants, that the variance explained by each chromosome is linearly related to its length (r = 0.89, P = 2.6 × 10(-8)), that the genetic basis of schizophrenia is the same in males and females, and that a disproportionate proportion of variation is attributable to a set of 2,725 genes expressed in the central nervous system (CNS; P = 7.6 × 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases.
U2 - 10.1038/ng.1108
DO - 10.1038/ng.1108
M3 - Journal article
VL - 44
SP - 247
EP - 250
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 3
ER -
ID: 48610743