Effekten af nitrogenoxiddonoren glyceryltrinitrat på humane smertetaerskler for tryk
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Effekten af nitrogenoxiddonoren glyceryltrinitrat på humane smertetaerskler for tryk. / Thomsen, L L; Brennum, J; Iversen, Helle Klingenberg; Olesen, J.
I: Ugeskrift for Laeger, Bind 159, Nr. 30, 21.07.1997, s. 4645-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Effekten af nitrogenoxiddonoren glyceryltrinitrat på humane smertetaerskler for tryk
AU - Thomsen, L L
AU - Brennum, J
AU - Iversen, Helle Klingenberg
AU - Olesen, J
PY - 1997/7/21
Y1 - 1997/7/21
N2 - The purpose of the present study was to examine the effect of the nitric oxide (NO) donor glyceryl trinitrate (GTN) on nociceptive thresholds in man. On two different study days twelve healthy subjects received a stair case infusion of GTN (0.015, 0.25, 1.0, 2.0 micrograms/kg/min 20 min each dose) or placebo in a randomized double-blind cross-over design. Before the infusion and after 15 min of infusion on each dose, pressure pain detection- and tolerance thresholds were determined by pressure algometry in three different anatomic regions (finger, a temporal region with interposed myofascial tissue and a temporal region without interposed myofascial tissue). Relative to placebo the three higher GTN doses induced a decrease in both detection- and tolerance-thresholds in the temporal region with interposed myofascial tissue. No such changes were observed in the two other stimulated regions. These results could reflect central facilitation of nociception by NO. However, convergence of nociceptive input from pericranial myofascial tissue and from cephalic blood vessels dilated by NO may provide a more likely explanation.
AB - The purpose of the present study was to examine the effect of the nitric oxide (NO) donor glyceryl trinitrate (GTN) on nociceptive thresholds in man. On two different study days twelve healthy subjects received a stair case infusion of GTN (0.015, 0.25, 1.0, 2.0 micrograms/kg/min 20 min each dose) or placebo in a randomized double-blind cross-over design. Before the infusion and after 15 min of infusion on each dose, pressure pain detection- and tolerance thresholds were determined by pressure algometry in three different anatomic regions (finger, a temporal region with interposed myofascial tissue and a temporal region without interposed myofascial tissue). Relative to placebo the three higher GTN doses induced a decrease in both detection- and tolerance-thresholds in the temporal region with interposed myofascial tissue. No such changes were observed in the two other stimulated regions. These results could reflect central facilitation of nociception by NO. However, convergence of nociceptive input from pericranial myofascial tissue and from cephalic blood vessels dilated by NO may provide a more likely explanation.
KW - Adult
KW - Cross-Over Studies
KW - Double-Blind Method
KW - Female
KW - Humans
KW - Infusions, Intravenous
KW - Male
KW - Neurotransmitter Agents
KW - Nitric Oxide
KW - Nitroglycerin
KW - Nociceptors
KW - Pain Threshold
KW - Pressure
KW - Vasodilator Agents
M3 - Tidsskriftartikel
C2 - 9245041
VL - 159
SP - 4645
EP - 4648
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 30
ER -
ID: 128983893