Effects of oral glucose load on endothelial function and on insulin and glucose fluctuations in healthy individuals
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Effects of oral glucose load on endothelial function and on insulin and glucose fluctuations in healthy individuals. / Major-Pedersen, A; Ihlemann, N; Hermann, T S; Christiansen, B; Dominguez, H; Kveiborg, B.; Nielsen, D B; Svendsen, O L; Køber, L; Torp-Pedersen, C.
I: Experimental Diabetes Research, Bind 2008, 2008, s. 672021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effects of oral glucose load on endothelial function and on insulin and glucose fluctuations in healthy individuals
AU - Major-Pedersen, A
AU - Ihlemann, N
AU - Hermann, T S
AU - Christiansen, B
AU - Dominguez, H
AU - Kveiborg, B.
AU - Nielsen, D B
AU - Svendsen, O L
AU - Køber, L
AU - Torp-Pedersen, C
N1 - Keywords: Blood Glucose; Blood Pressure; Electrocardiography; Endothelium, Vascular; Glucose; Glucose Tolerance Test; Humans; Insulin; Kinetics; Placebos; Reference Values
PY - 2008
Y1 - 2008
N2 - BACKGROUND/AIMS: Postprandial hyperglycemia, an independent risk factor for cardiovascular disease, is accompanied by endothelial dysfunction. We studied the effect of oral glucose load on insulin and glucose fluctuations, and on postprandial endothelial function in healthy individuals in order to better understand and cope with the postprandial state in insulin resistant individuals. METHODS: We assessed post-oral glucose load endothelial function (flow mediated dilation), plasma insulin, and blood glucose in 9 healthy subjects. RESULTS: The largest increases in delta FMD values (fasting FMD value subtracted from postprandial FMD value) occurred at 3 hours after both glucose or placebo load, respectively: 4.80 +/- 1.41 (P = .009) and 2.34 +/- 1.47 (P = .15). Glucose and insulin concentrations achieved maximum peaks at one hour post-glucose load. CONCLUSION: Oral glucose load does not induce endothelial dysfunction in healthy individuals with mean insulin and glucose values of 5.6 mmol/L and 27.2 mmol/L, respectively, 2 hours after glucose load.
AB - BACKGROUND/AIMS: Postprandial hyperglycemia, an independent risk factor for cardiovascular disease, is accompanied by endothelial dysfunction. We studied the effect of oral glucose load on insulin and glucose fluctuations, and on postprandial endothelial function in healthy individuals in order to better understand and cope with the postprandial state in insulin resistant individuals. METHODS: We assessed post-oral glucose load endothelial function (flow mediated dilation), plasma insulin, and blood glucose in 9 healthy subjects. RESULTS: The largest increases in delta FMD values (fasting FMD value subtracted from postprandial FMD value) occurred at 3 hours after both glucose or placebo load, respectively: 4.80 +/- 1.41 (P = .009) and 2.34 +/- 1.47 (P = .15). Glucose and insulin concentrations achieved maximum peaks at one hour post-glucose load. CONCLUSION: Oral glucose load does not induce endothelial dysfunction in healthy individuals with mean insulin and glucose values of 5.6 mmol/L and 27.2 mmol/L, respectively, 2 hours after glucose load.
U2 - 10.1155/2008/672021
DO - 10.1155/2008/672021
M3 - Journal article
C2 - 18350125
VL - 2008
SP - 672021
JO - Journal of Diabetes Research
JF - Journal of Diabetes Research
SN - 2314-6745
ER -
ID: 17398098