Effect of oral proguanil on human lymphocyte proliferation
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Effect of oral proguanil on human lymphocyte proliferation. / Bygbjerg, Ib Christian; Flachs, H.
I: European Journal of Clinical Pharmacology, Bind 30, Nr. 2, 01.01.1986, s. 249-51.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effect of oral proguanil on human lymphocyte proliferation
AU - Bygbjerg, Ib Christian
AU - Flachs, H
PY - 1986/1/1
Y1 - 1986/1/1
N2 - In vitro studies have indicated that the antifolates pyrimethamine [4, 6] and cycloguanil (the active metabolite of proguanil) suppress the proliferation of stimulated human lymphocytes; proguanil has no effect [2]. During the early growth phase of the cells, 14C-thymidine (14C-TdR) incorporation is increased by pyrimethamine and cycloguanil, reflecting blockage of endogenous TdR synthesis [3]. Proguanil (Paludrine) is increasingly being used for malaria prophylaxis. It is considered the most innocuous of the antimalarials currently employed. Since nothing is known about the effect of oral proguanil on human lymphocytes, the present study was undertaken. Little information is available about the serum levels of proguanil and cycloguanil following ingestion of prophylactic doses [8]. Therefore, the serum concentrations of proguanil and cycloguanil were estimated, to allow comparison with previous in vitro studies [2].
AB - In vitro studies have indicated that the antifolates pyrimethamine [4, 6] and cycloguanil (the active metabolite of proguanil) suppress the proliferation of stimulated human lymphocytes; proguanil has no effect [2]. During the early growth phase of the cells, 14C-thymidine (14C-TdR) incorporation is increased by pyrimethamine and cycloguanil, reflecting blockage of endogenous TdR synthesis [3]. Proguanil (Paludrine) is increasingly being used for malaria prophylaxis. It is considered the most innocuous of the antimalarials currently employed. Since nothing is known about the effect of oral proguanil on human lymphocytes, the present study was undertaken. Little information is available about the serum levels of proguanil and cycloguanil following ingestion of prophylactic doses [8]. Therefore, the serum concentrations of proguanil and cycloguanil were estimated, to allow comparison with previous in vitro studies [2].
KW - Adult
KW - Humans
KW - Leukocyte Count
KW - Leukocytes
KW - Lymphocyte Activation
KW - Lymphocytes
KW - Phytohemagglutinins
KW - Proguanil
KW - Pyrimethamine
KW - Thymidine
KW - Time Factors
KW - Triazines
M3 - Journal article
C2 - 3709655
VL - 30
SP - 249
EP - 251
JO - European Journal of Clinical Pharmacology
JF - European Journal of Clinical Pharmacology
SN - 0031-6970
IS - 2
ER -
ID: 33891791