Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia
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Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia. / Bygbjerg, Ib Christian; Lund, J T; Hørding, M.
I: Scandinavian Journal of Infectious Diseases, Bind 20, Nr. 6, 01.01.1988, s. 685-6.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia
AU - Bygbjerg, Ib Christian
AU - Lund, J T
AU - Hørding, M
PY - 1988/1/1
Y1 - 1988/1/1
N2 - 12 AIDS/ARC patients with or suspected of Pneumocystis carinii pneumonia were treated with co-trimoxazole and received supplementary folic or folinic acid to avoid peripheral blood cytopenia. Most patients developed decreased numbers of neutrophils and hemoglobin while receiving co-trimoxazole. Supplementary folate/folinate could not abolish the drug-induced cytopenia. Routine prescription of folinic acid is not recommended. Folic acid is cheap and may be beneficial and should be prescribed.
AB - 12 AIDS/ARC patients with or suspected of Pneumocystis carinii pneumonia were treated with co-trimoxazole and received supplementary folic or folinic acid to avoid peripheral blood cytopenia. Most patients developed decreased numbers of neutrophils and hemoglobin while receiving co-trimoxazole. Supplementary folate/folinate could not abolish the drug-induced cytopenia. Routine prescription of folinic acid is not recommended. Folic acid is cheap and may be beneficial and should be prescribed.
KW - AIDS-Related Complex
KW - Acquired Immunodeficiency Syndrome
KW - Anemia
KW - Drug Combinations
KW - Folic Acid
KW - Hematologic Diseases
KW - Humans
KW - Leucovorin
KW - Leukopenia
KW - Pneumonia, Pneumocystis
KW - Prospective Studies
KW - Sulfamethoxazole
KW - Thrombocytopenia
KW - Time Factors
KW - Trimethoprim
KW - Trimethoprim-Sulfamethoxazole Combination
M3 - Journal article
C2 - 3265540
VL - 20
SP - 685
EP - 686
JO - Infectious Diseases
JF - Infectious Diseases
SN - 2374-4235
IS - 6
ER -
ID: 33891505