Effect of CGRP and sumatriptan on the BOLD response in visual cortex

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Effect of CGRP and sumatriptan on the BOLD response in visual cortex. / Asghar, Mohammed Sohail; Hansen, Adam E; Larsson, Henrik B W; Ashina, Messoud; Olesen, Jes.

I: Journal of Headache and Pain, 2012, s. 159-66.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Asghar, MS, Hansen, AE, Larsson, HBW, Ashina, M & Olesen, J 2012, 'Effect of CGRP and sumatriptan on the BOLD response in visual cortex', Journal of Headache and Pain, s. 159-66. https://doi.org/10.1007/s10194-011-0415-4

APA

Asghar, M. S., Hansen, A. E., Larsson, H. B. W., Ashina, M., & Olesen, J. (2012). Effect of CGRP and sumatriptan on the BOLD response in visual cortex. Journal of Headache and Pain, 159-66. https://doi.org/10.1007/s10194-011-0415-4

Vancouver

Asghar MS, Hansen AE, Larsson HBW, Ashina M, Olesen J. Effect of CGRP and sumatriptan on the BOLD response in visual cortex. Journal of Headache and Pain. 2012;159-66. https://doi.org/10.1007/s10194-011-0415-4

Author

Asghar, Mohammed Sohail ; Hansen, Adam E ; Larsson, Henrik B W ; Ashina, Messoud ; Olesen, Jes. / Effect of CGRP and sumatriptan on the BOLD response in visual cortex. I: Journal of Headache and Pain. 2012 ; s. 159-66.

Bibtex

@article{d175ba27d8f0450fb160ebe308c2ebbd,
title = "Effect of CGRP and sumatriptan on the BOLD response in visual cortex",
abstract = "To test the hypothesis that calcitonin gene-related peptide (CGRP) modulates brain activity, we investigated the effect of intravenous CGRP on brain activity in response to a visual stimulus. In addition, we examined if possible alteration in brain activity was reversed by the anti-migraine drug sumatriptan. Eighteen healthy volunteers were randomly allocated to receive CGRP infusion (1.5 µg/min for 20 min) or placebo. In vivo activity in the visual cortex was recorded before, during and after infusion and after 6 mg subcutaneous sumatriptan by functional magnetic resonance imaging (3 T). 77% of the participants reported headache after CGRP. We found no changes in brain activity after CGRP (P = 0.12) or after placebo (P = 0.41). Sumatriptan did not affect brain activity after CGRP (P = 0.71) or after placebo (P = 0.98). Systemic CGRP or sumatriptan has no direct effects on the BOLD activity in visual cortex. This suggests that in healthy volunteers both CGRP and sumatriptan may exert their actions outside of the blood-brain barrier.",
author = "Asghar, {Mohammed Sohail} and Hansen, {Adam E} and Larsson, {Henrik B W} and Messoud Ashina and Jes Olesen",
year = "2012",
doi = "10.1007/s10194-011-0415-4",
language = "English",
pages = "159--66",
journal = "Journal of Headache and Pain",
issn = "1129-2369",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Effect of CGRP and sumatriptan on the BOLD response in visual cortex

AU - Asghar, Mohammed Sohail

AU - Hansen, Adam E

AU - Larsson, Henrik B W

AU - Ashina, Messoud

AU - Olesen, Jes

PY - 2012

Y1 - 2012

N2 - To test the hypothesis that calcitonin gene-related peptide (CGRP) modulates brain activity, we investigated the effect of intravenous CGRP on brain activity in response to a visual stimulus. In addition, we examined if possible alteration in brain activity was reversed by the anti-migraine drug sumatriptan. Eighteen healthy volunteers were randomly allocated to receive CGRP infusion (1.5 µg/min for 20 min) or placebo. In vivo activity in the visual cortex was recorded before, during and after infusion and after 6 mg subcutaneous sumatriptan by functional magnetic resonance imaging (3 T). 77% of the participants reported headache after CGRP. We found no changes in brain activity after CGRP (P = 0.12) or after placebo (P = 0.41). Sumatriptan did not affect brain activity after CGRP (P = 0.71) or after placebo (P = 0.98). Systemic CGRP or sumatriptan has no direct effects on the BOLD activity in visual cortex. This suggests that in healthy volunteers both CGRP and sumatriptan may exert their actions outside of the blood-brain barrier.

AB - To test the hypothesis that calcitonin gene-related peptide (CGRP) modulates brain activity, we investigated the effect of intravenous CGRP on brain activity in response to a visual stimulus. In addition, we examined if possible alteration in brain activity was reversed by the anti-migraine drug sumatriptan. Eighteen healthy volunteers were randomly allocated to receive CGRP infusion (1.5 µg/min for 20 min) or placebo. In vivo activity in the visual cortex was recorded before, during and after infusion and after 6 mg subcutaneous sumatriptan by functional magnetic resonance imaging (3 T). 77% of the participants reported headache after CGRP. We found no changes in brain activity after CGRP (P = 0.12) or after placebo (P = 0.41). Sumatriptan did not affect brain activity after CGRP (P = 0.71) or after placebo (P = 0.98). Systemic CGRP or sumatriptan has no direct effects on the BOLD activity in visual cortex. This suggests that in healthy volunteers both CGRP and sumatriptan may exert their actions outside of the blood-brain barrier.

U2 - 10.1007/s10194-011-0415-4

DO - 10.1007/s10194-011-0415-4

M3 - Journal article

C2 - 22246026

SP - 159

EP - 166

JO - Journal of Headache and Pain

JF - Journal of Headache and Pain

SN - 1129-2369

ER -

ID: 40140843