Effect of advanced chronic kidney disease in clinical and echocardiographic outcomes of patients treated with MitraClip system
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Effect of advanced chronic kidney disease in clinical and echocardiographic outcomes of patients treated with MitraClip system. / Estévez-Loureiro, Rodrigo; Settergren, Magnus; Pighi, Michele; Winter, Reidar; D'Allara, Gianni; Jacobsen, Per; Sondergaard, Lars; Cheung, Gary; Ghione, Matteo; Ihlemann, Nikolaj; Moat, Neil E; Price, Susanna; Rosenberg, Tine Streit; Di Mario, Carlo; Franzen, Olaf.
I: International Journal of Cardiology, Bind 198, 01.11.2015, s. 75-80.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Effect of advanced chronic kidney disease in clinical and echocardiographic outcomes of patients treated with MitraClip system
AU - Estévez-Loureiro, Rodrigo
AU - Settergren, Magnus
AU - Pighi, Michele
AU - Winter, Reidar
AU - D'Allara, Gianni
AU - Jacobsen, Per
AU - Sondergaard, Lars
AU - Cheung, Gary
AU - Ghione, Matteo
AU - Ihlemann, Nikolaj
AU - Moat, Neil E
AU - Price, Susanna
AU - Rosenberg, Tine Streit
AU - Di Mario, Carlo
AU - Franzen, Olaf
N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - BACKGROUND: Data regarding the influence of different levels of renal dysfunction on clinical and echocardiographic results of MitraClip therapy are scarce. We aimed to evaluate the impact of baseline advance renal failure in the outcomes of a cohort of patients treated with MitraClip.METHODS AND RESULTS: We analyzed data from a multicenter registry of 173 patients treated with MitraClip between 2009 and 2012. Patients were classified as advanced chronic kidney disease (CKD, creatinine clearance [CrCl] <30 ml/min, group 1, n=20), moderate CKD (CrCl 30-60 ml/min, group 2, n=78) and normal renal function (CrCl >60 ml/min, group 3, n=75). Twenty patients (11.5%) presented advanced CKD. Procedural success was equal in the 3 groups (95.0% group 1, 100% in group 2 and 96.0% in group 3, p=0.180). Post-procedural MR and NYHA class at 1 month (MR ≥ 3+5.0% vs. 0% vs. 4.0% p=0.190 and NYHA>II 40.0% vs. 21.0% vs. 18.3%, p=0.101) and 6 months (MR ≥ 3+0% vs. 13.0% vs. 2.7%, p=0.330; and NYHA class>II 54.5% vs. 26.9% vs. 25.6%, p=0.298) did not differ between groups. However, patients in group 1 experienced higher frequency of the composite end-point of mortality or readmission at 16.2 ± 11.1 months of follow-up (HR 4.8, CI 95% 1.1-21.3).CONCLUSION: Advanced CKD is linked to an excess of cardiac adverse events. This should be judiciously taken into account when selecting patients for MitraClip.
AB - BACKGROUND: Data regarding the influence of different levels of renal dysfunction on clinical and echocardiographic results of MitraClip therapy are scarce. We aimed to evaluate the impact of baseline advance renal failure in the outcomes of a cohort of patients treated with MitraClip.METHODS AND RESULTS: We analyzed data from a multicenter registry of 173 patients treated with MitraClip between 2009 and 2012. Patients were classified as advanced chronic kidney disease (CKD, creatinine clearance [CrCl] <30 ml/min, group 1, n=20), moderate CKD (CrCl 30-60 ml/min, group 2, n=78) and normal renal function (CrCl >60 ml/min, group 3, n=75). Twenty patients (11.5%) presented advanced CKD. Procedural success was equal in the 3 groups (95.0% group 1, 100% in group 2 and 96.0% in group 3, p=0.180). Post-procedural MR and NYHA class at 1 month (MR ≥ 3+5.0% vs. 0% vs. 4.0% p=0.190 and NYHA>II 40.0% vs. 21.0% vs. 18.3%, p=0.101) and 6 months (MR ≥ 3+0% vs. 13.0% vs. 2.7%, p=0.330; and NYHA class>II 54.5% vs. 26.9% vs. 25.6%, p=0.298) did not differ between groups. However, patients in group 1 experienced higher frequency of the composite end-point of mortality or readmission at 16.2 ± 11.1 months of follow-up (HR 4.8, CI 95% 1.1-21.3).CONCLUSION: Advanced CKD is linked to an excess of cardiac adverse events. This should be judiciously taken into account when selecting patients for MitraClip.
U2 - 10.1016/j.ijcard.2015.06.137
DO - 10.1016/j.ijcard.2015.06.137
M3 - Journal article
C2 - 26156318
VL - 198
SP - 75
EP - 80
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -
ID: 162597363