Effect of a common variant of the PCSK2 gene on reduced insulin secretion

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Standard

Effect of a common variant of the PCSK2 gene on reduced insulin secretion. / Jonsson, Anna Elisabet; Isomaa, B; Tuomi, T; Eriksson, J G; Groop, L; Lyssenko, V.

I: Diabetologia, Bind 55, Nr. 12, 12.2012, s. 3245-51.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jonsson, AE, Isomaa, B, Tuomi, T, Eriksson, JG, Groop, L & Lyssenko, V 2012, 'Effect of a common variant of the PCSK2 gene on reduced insulin secretion', Diabetologia, bind 55, nr. 12, s. 3245-51. https://doi.org/10.1007/s00125-012-2728-5

APA

Jonsson, A. E., Isomaa, B., Tuomi, T., Eriksson, J. G., Groop, L., & Lyssenko, V. (2012). Effect of a common variant of the PCSK2 gene on reduced insulin secretion. Diabetologia, 55(12), 3245-51. https://doi.org/10.1007/s00125-012-2728-5

Vancouver

Jonsson AE, Isomaa B, Tuomi T, Eriksson JG, Groop L, Lyssenko V. Effect of a common variant of the PCSK2 gene on reduced insulin secretion. Diabetologia. 2012 dec.;55(12):3245-51. https://doi.org/10.1007/s00125-012-2728-5

Author

Jonsson, Anna Elisabet ; Isomaa, B ; Tuomi, T ; Eriksson, J G ; Groop, L ; Lyssenko, V. / Effect of a common variant of the PCSK2 gene on reduced insulin secretion. I: Diabetologia. 2012 ; Bind 55, Nr. 12. s. 3245-51.

Bibtex

@article{7b9d56e7c822463e82e80c6b33d2f48b,
title = "Effect of a common variant of the PCSK2 gene on reduced insulin secretion",
abstract = "Individuals at risk of developing type 2 diabetes show a progressive decline in insulin secretion and increased insulin resistance over time. However, inability of the beta cells to compensate for the increased insulin resistance represents a key defect leading to overt type 2 diabetes. The aims of the present study were to replicate the association between genetic variants of the PCSK2 gene and insulin secretion, and to explore the effect on risk of type 2 diabetes.",
keywords = "Aged, Blood Glucose, Fasting, Female, Finland, Follow-Up Studies, Genetic Variation, Genotype, Humans, Insulin, Insulin Resistance, Islets of Langerhans, Male, Middle Aged, Predictive Value of Tests, Proprotein Convertase 2, Prospective Studies, Risk Assessment, Sweden",
author = "Jonsson, {Anna Elisabet} and B Isomaa and T Tuomi and Eriksson, {J G} and L Groop and V Lyssenko",
year = "2012",
month = dec,
doi = "10.1007/s00125-012-2728-5",
language = "English",
volume = "55",
pages = "3245--51",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "12",

}

RIS

TY - JOUR

T1 - Effect of a common variant of the PCSK2 gene on reduced insulin secretion

AU - Jonsson, Anna Elisabet

AU - Isomaa, B

AU - Tuomi, T

AU - Eriksson, J G

AU - Groop, L

AU - Lyssenko, V

PY - 2012/12

Y1 - 2012/12

N2 - Individuals at risk of developing type 2 diabetes show a progressive decline in insulin secretion and increased insulin resistance over time. However, inability of the beta cells to compensate for the increased insulin resistance represents a key defect leading to overt type 2 diabetes. The aims of the present study were to replicate the association between genetic variants of the PCSK2 gene and insulin secretion, and to explore the effect on risk of type 2 diabetes.

AB - Individuals at risk of developing type 2 diabetes show a progressive decline in insulin secretion and increased insulin resistance over time. However, inability of the beta cells to compensate for the increased insulin resistance represents a key defect leading to overt type 2 diabetes. The aims of the present study were to replicate the association between genetic variants of the PCSK2 gene and insulin secretion, and to explore the effect on risk of type 2 diabetes.

KW - Aged

KW - Blood Glucose

KW - Fasting

KW - Female

KW - Finland

KW - Follow-Up Studies

KW - Genetic Variation

KW - Genotype

KW - Humans

KW - Insulin

KW - Insulin Resistance

KW - Islets of Langerhans

KW - Male

KW - Middle Aged

KW - Predictive Value of Tests

KW - Proprotein Convertase 2

KW - Prospective Studies

KW - Risk Assessment

KW - Sweden

U2 - 10.1007/s00125-012-2728-5

DO - 10.1007/s00125-012-2728-5

M3 - Journal article

C2 - 23011353

VL - 55

SP - 3245

EP - 3251

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 12

ER -

ID: 46403756