Effect of a common variant of the PCSK2 gene on reduced insulin secretion
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Effect of a common variant of the PCSK2 gene on reduced insulin secretion. / Jonsson, Anna Elisabet; Isomaa, B; Tuomi, T; Eriksson, J G; Groop, L; Lyssenko, V.
I: Diabetologia, Bind 55, Nr. 12, 12.2012, s. 3245-51.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effect of a common variant of the PCSK2 gene on reduced insulin secretion
AU - Jonsson, Anna Elisabet
AU - Isomaa, B
AU - Tuomi, T
AU - Eriksson, J G
AU - Groop, L
AU - Lyssenko, V
PY - 2012/12
Y1 - 2012/12
N2 - Individuals at risk of developing type 2 diabetes show a progressive decline in insulin secretion and increased insulin resistance over time. However, inability of the beta cells to compensate for the increased insulin resistance represents a key defect leading to overt type 2 diabetes. The aims of the present study were to replicate the association between genetic variants of the PCSK2 gene and insulin secretion, and to explore the effect on risk of type 2 diabetes.
AB - Individuals at risk of developing type 2 diabetes show a progressive decline in insulin secretion and increased insulin resistance over time. However, inability of the beta cells to compensate for the increased insulin resistance represents a key defect leading to overt type 2 diabetes. The aims of the present study were to replicate the association between genetic variants of the PCSK2 gene and insulin secretion, and to explore the effect on risk of type 2 diabetes.
KW - Aged
KW - Blood Glucose
KW - Fasting
KW - Female
KW - Finland
KW - Follow-Up Studies
KW - Genetic Variation
KW - Genotype
KW - Humans
KW - Insulin
KW - Insulin Resistance
KW - Islets of Langerhans
KW - Male
KW - Middle Aged
KW - Predictive Value of Tests
KW - Proprotein Convertase 2
KW - Prospective Studies
KW - Risk Assessment
KW - Sweden
U2 - 10.1007/s00125-012-2728-5
DO - 10.1007/s00125-012-2728-5
M3 - Journal article
C2 - 23011353
VL - 55
SP - 3245
EP - 3251
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 12
ER -
ID: 46403756