Early feeding and risk of type 1 diabetes: experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR)
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Early feeding and risk of type 1 diabetes : experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR). / Knip, Mikael; Virtanen, Suvi M; Becker, Dorothy; Dupré, John; Krischer, Jeffrey P; Åkerblom, Hans K; TRIGR Study Group ; Mandrup-Poulsen, Thomas.
I: American Journal of Clinical Nutrition, Bind 94, Nr. 6 Suppl, 2011, s. 1814S-1820S.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Early feeding and risk of type 1 diabetes
T2 - experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR)
AU - Knip, Mikael
AU - Virtanen, Suvi M
AU - Becker, Dorothy
AU - Dupré, John
AU - Krischer, Jeffrey P
AU - Åkerblom, Hans K
AU - TRIGR Study Group
AU - Mandrup-Poulsen, Thomas
PY - 2011
Y1 - 2011
N2 - Short-term breastfeeding and early exposure to complex dietary proteins, such as cow milk proteins and cereals, or to fruit, berries, and roots have been implicated as risk factors for ß cell autoimmunity, clinical type 1 diabetes, or both. The Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR) is an international, randomized, double-blind, controlled intervention trial designed to answer the question of whether weaning to an extensively hydrolyzed formula in infancy will decrease the risk of type 1 diabetes later in childhood. In our pilot study, weaning to a highly hydrolyzed formula decreased by ˜ 50% the cumulative incidence of one or more diabetes-associated autoantibodies by a mean age of 4.7 y. This finding was confirmed in a recent follow-up analysis to 10 y of age. Currently, the full-scale TRIGR takes place in 77 centers in 15 countries. The TRIGR initially recruited 5606 newborn infants with a family member affected by type 1 diabetes and enrolled 2159 eligible subjects who carried a risk-conferring HLA genotype. All recruited mothers were encouraged to breastfeed. The intervention lasted for 6-8 mo with a minimum study formula exposure time of 2 mo, and hydrolyzed casein and standard cow milk-based weaning formulas were compared. Eighty percent of the participants were exposed to the study formula. The overall retention rate over the first 5 y was 87%, and protocol compliance was 94%. The randomization code will be opened when the last recruited child turns 10 y of age (ie, in 2017).
AB - Short-term breastfeeding and early exposure to complex dietary proteins, such as cow milk proteins and cereals, or to fruit, berries, and roots have been implicated as risk factors for ß cell autoimmunity, clinical type 1 diabetes, or both. The Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR) is an international, randomized, double-blind, controlled intervention trial designed to answer the question of whether weaning to an extensively hydrolyzed formula in infancy will decrease the risk of type 1 diabetes later in childhood. In our pilot study, weaning to a highly hydrolyzed formula decreased by ˜ 50% the cumulative incidence of one or more diabetes-associated autoantibodies by a mean age of 4.7 y. This finding was confirmed in a recent follow-up analysis to 10 y of age. Currently, the full-scale TRIGR takes place in 77 centers in 15 countries. The TRIGR initially recruited 5606 newborn infants with a family member affected by type 1 diabetes and enrolled 2159 eligible subjects who carried a risk-conferring HLA genotype. All recruited mothers were encouraged to breastfeed. The intervention lasted for 6-8 mo with a minimum study formula exposure time of 2 mo, and hydrolyzed casein and standard cow milk-based weaning formulas were compared. Eighty percent of the participants were exposed to the study formula. The overall retention rate over the first 5 y was 87%, and protocol compliance was 94%. The randomization code will be opened when the last recruited child turns 10 y of age (ie, in 2017).
KW - Autoimmunity
KW - Breast Feeding
KW - Child
KW - Child, Preschool
KW - Diabetes Mellitus, Type 1
KW - Dietary Proteins
KW - Double-Blind Method
KW - Follow-Up Studies
KW - Genetic Predisposition to Disease
KW - Genotype
KW - HLA Antigens
KW - Humans
KW - Incidence
KW - Infant
KW - Infant Formula
KW - Infant, Newborn
KW - Milk Proteins
KW - Multicenter Studies as Topic
KW - Pilot Projects
KW - Randomized Controlled Trials as Topic
KW - Risk Factors
KW - Weaning
U2 - 10.3945/ajcn.110.000711
DO - 10.3945/ajcn.110.000711
M3 - Journal article
C2 - 21653795
VL - 94
SP - 1814S-1820S
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 6 Suppl
ER -
ID: 38412770