Dynamics of cortical and corticomuscular connectivity during planning and execution of visually guided steps in humans
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Dynamics of cortical and corticomuscular connectivity during planning and execution of visually guided steps in humans. / Spedden, Meaghan Elizabeth; Beck, Mikkel Malling; West, Timothy O; Farmer, Simon F; Nielsen, Jens Bo; Lundbye-Jensen, Jesper.
I: Cerebral Cortex, Bind 33, Nr. 2, 2023, s. 258–277.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Dynamics of cortical and corticomuscular connectivity during planning and execution of visually guided steps in humans
AU - Spedden, Meaghan Elizabeth
AU - Beck, Mikkel Malling
AU - West, Timothy O
AU - Farmer, Simon F
AU - Nielsen, Jens Bo
AU - Lundbye-Jensen, Jesper
N1 - © The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PY - 2023
Y1 - 2023
N2 - The cortical mechanisms underlying the act of taking a step-including planning, execution, and modification - are not well understood. We hypothesized that oscillatory communication in a parieto-frontal and corticomuscular network is involved in the neural control of visually guided steps. We addressed this hypothesis using source reconstruction and lagged coherence analysis of electroencephalographic and electromyographic recordings during visually guided stepping and 2 control tasks that aimed to investigate processes involved in (i) preparing and taking a step and (ii) adjusting a step based on visual information. Steps were divided into planning, initiation, and execution phases. Taking a step was characterized by an upregulation of beta/gamma coherence within the parieto-frontal network during planning followed by a downregulation of alpha and beta/gamma coherence during initiation and execution. Step modification was characterized by bidirectional modulations of alpha and beta/gamma coherence in the parieto-frontal network during the phases leading up to step execution. Corticomuscular coherence did not exhibit task-related effects. We suggest that these task-related modulations indicate that the brain makes use of communication through coherence in the context of large-scale, whole-body movements, reflecting a process of flexibly fine-tuning inter-regional communication to achieve precision control during human stepping.
AB - The cortical mechanisms underlying the act of taking a step-including planning, execution, and modification - are not well understood. We hypothesized that oscillatory communication in a parieto-frontal and corticomuscular network is involved in the neural control of visually guided steps. We addressed this hypothesis using source reconstruction and lagged coherence analysis of electroencephalographic and electromyographic recordings during visually guided stepping and 2 control tasks that aimed to investigate processes involved in (i) preparing and taking a step and (ii) adjusting a step based on visual information. Steps were divided into planning, initiation, and execution phases. Taking a step was characterized by an upregulation of beta/gamma coherence within the parieto-frontal network during planning followed by a downregulation of alpha and beta/gamma coherence during initiation and execution. Step modification was characterized by bidirectional modulations of alpha and beta/gamma coherence in the parieto-frontal network during the phases leading up to step execution. Corticomuscular coherence did not exhibit task-related effects. We suggest that these task-related modulations indicate that the brain makes use of communication through coherence in the context of large-scale, whole-body movements, reflecting a process of flexibly fine-tuning inter-regional communication to achieve precision control during human stepping.
KW - Faculty of Science
KW - Coherence
KW - EEG
KW - EMG
KW - Stepping
KW - Walking
U2 - 10.1093/cercor/bhac066
DO - 10.1093/cercor/bhac066
M3 - Journal article
C2 - 35238339
VL - 33
SP - 258
EP - 277
JO - Cerebral Cortex
JF - Cerebral Cortex
SN - 1047-3211
IS - 2
ER -
ID: 299394225