Dynamic changes in LH/FSH ratios in infants with normal sex development
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Dynamic changes in LH/FSH ratios in infants with normal sex development. / Ljubicic, Marie Lindhardt; Busch, Alexander S.; Upners, Emmie N.; Fischer, Margit Bistrup; Main, Katharina M.; Andersson, Anna Maria; Johannsen, Trine Holm; Hagen, Casper P.; Juul, Anders.
I: European Journal of Endocrinology, Bind 187, Nr. 1, 2022, s. 135-142.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Dynamic changes in LH/FSH ratios in infants with normal sex development
AU - Ljubicic, Marie Lindhardt
AU - Busch, Alexander S.
AU - Upners, Emmie N.
AU - Fischer, Margit Bistrup
AU - Main, Katharina M.
AU - Andersson, Anna Maria
AU - Johannsen, Trine Holm
AU - Hagen, Casper P.
AU - Juul, Anders
PY - 2022
Y1 - 2022
N2 - Objective: Little is known about the ratio between luteinizing hormone (LH) and follicle-stimulating hormone (FSH) during infancy. This study aimed to evaluate serum and urinary LH/FSH as a marker of sex with age-specific cutoffs in healthy infants. Design: A prospective, longitudinal cohort study of healthy infants aged 0-1.2 years. Methods: In total, 236 healthy infants (122 boys and 114 girls) from The COPENHAGEN Minipuberty Study (ClinicalTrials.gov ID: NCT02784184), with 567 serum and 603 urine samples, were included. Measures of diagnostic accuracy, including sensitivity and specificity, were used to assess the ability of LH/FSH to detect sex in healthy infants. Results: In both serum and urine, LH/FSH was highest in males with minimal overlap between the sexes. In contrast to isolated LH and FSH concentrations, LH/FSH ratios in both serum and urine were excellent markers of sex from 0 to 1.2 years with median sensitivities and specificities ranging from 93 to 100% with correspondingly narrow 95% CIs. Conclusions: Serum and urinary LH/FSH ratios are excellent discriminators of sex in healthy infants during the entire first year of life. The clinical role and application of the ratio remain to be elucidated.
AB - Objective: Little is known about the ratio between luteinizing hormone (LH) and follicle-stimulating hormone (FSH) during infancy. This study aimed to evaluate serum and urinary LH/FSH as a marker of sex with age-specific cutoffs in healthy infants. Design: A prospective, longitudinal cohort study of healthy infants aged 0-1.2 years. Methods: In total, 236 healthy infants (122 boys and 114 girls) from The COPENHAGEN Minipuberty Study (ClinicalTrials.gov ID: NCT02784184), with 567 serum and 603 urine samples, were included. Measures of diagnostic accuracy, including sensitivity and specificity, were used to assess the ability of LH/FSH to detect sex in healthy infants. Results: In both serum and urine, LH/FSH was highest in males with minimal overlap between the sexes. In contrast to isolated LH and FSH concentrations, LH/FSH ratios in both serum and urine were excellent markers of sex from 0 to 1.2 years with median sensitivities and specificities ranging from 93 to 100% with correspondingly narrow 95% CIs. Conclusions: Serum and urinary LH/FSH ratios are excellent discriminators of sex in healthy infants during the entire first year of life. The clinical role and application of the ratio remain to be elucidated.
U2 - 10.1530/EJE-21-0999
DO - 10.1530/EJE-21-0999
M3 - Journal article
C2 - 35521767
AN - SCOPUS:85131270729
VL - 187
SP - 135
EP - 142
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 1
ER -
ID: 313705114