Distinct Hippocampal Oscillation Dynamics in Trace Eyeblink Conditioning Task for Retrieval and Consolidation of Associations
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Distinct Hippocampal Oscillation Dynamics in Trace Eyeblink Conditioning Task for Retrieval and Consolidation of Associations. / Kim, Kayeon; Nokia, Miriam S.; Palva, Satu.
I: eNeuro, Bind 11, Nr. 4, ENEURO.0030-23.2024, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Distinct Hippocampal Oscillation Dynamics in Trace Eyeblink Conditioning Task for Retrieval and Consolidation of Associations
AU - Kim, Kayeon
AU - Nokia, Miriam S.
AU - Palva, Satu
N1 - Publisher Copyright: © 2024 Kim et al.
PY - 2024
Y1 - 2024
N2 - Trace eyeblink conditioning (TEBC) has been widely used to study associative learning in both animals and humans. In this paradigm, conditioned responses (CRs) to conditioned stimuli (CS) serve as a measure for retrieving learned associations between the CS and the unconditioned stimuli (US) within a trial. Memory consolidation, that is, learning over time, can be quantified as an increase in the proportion of CRs across training sessions. However, how hippocampal oscillations differentiate between successful memory retrieval within a session and consolidation across TEBC training sessions remains unknown. To address this question, we recorded local field potentials (LFPs) from the rat dorsal hippocampus during TEBC and investigated hippocampal oscillation dynamics associated with these two functions. We show that transient broadband responses to the CS were correlated with memory consolidation, as indexed by an increase in CRs across TEBC sessions. In contrast, induced alpha (8–10 Hz) and beta (16–20 Hz) band responses were correlated with the successful retrieval of the CS–US association within a session, as indexed by the difference in trials with and without CR.
AB - Trace eyeblink conditioning (TEBC) has been widely used to study associative learning in both animals and humans. In this paradigm, conditioned responses (CRs) to conditioned stimuli (CS) serve as a measure for retrieving learned associations between the CS and the unconditioned stimuli (US) within a trial. Memory consolidation, that is, learning over time, can be quantified as an increase in the proportion of CRs across training sessions. However, how hippocampal oscillations differentiate between successful memory retrieval within a session and consolidation across TEBC training sessions remains unknown. To address this question, we recorded local field potentials (LFPs) from the rat dorsal hippocampus during TEBC and investigated hippocampal oscillation dynamics associated with these two functions. We show that transient broadband responses to the CS were correlated with memory consolidation, as indexed by an increase in CRs across TEBC sessions. In contrast, induced alpha (8–10 Hz) and beta (16–20 Hz) band responses were correlated with the successful retrieval of the CS–US association within a session, as indexed by the difference in trials with and without CR.
KW - classical conditioning
KW - cross-frequency coupling
KW - hippocampus
KW - memory
KW - phase locking
U2 - 10.1523/ENEURO.0030-23.2024
DO - 10.1523/ENEURO.0030-23.2024
M3 - Journal article
C2 - 38627063
AN - SCOPUS:85191324257
VL - 11
JO - eNeuro
JF - eNeuro
SN - 2373-2822
IS - 4
M1 - ENEURO.0030-23.2024
ER -
ID: 390818764