TY - JOUR

T1 - Distinct Hippocampal Oscillation Dynamics in Trace Eyeblink Conditioning Task for Retrieval and Consolidation of Associations

AU - Kim, Kayeon

AU - Nokia, Miriam S.

AU - Palva, Satu

N1 - Publisher Copyright: © 2024 Kim et al.

PY - 2024

Y1 - 2024

N2 - Trace eyeblink conditioning (TEBC) has been widely used to study associative learning in both animals and humans. In this paradigm, conditioned responses (CRs) to conditioned stimuli (CS) serve as a measure for retrieving learned associations between the CS and the unconditioned stimuli (US) within a trial. Memory consolidation, that is, learning over time, can be quantified as an increase in the proportion of CRs across training sessions. However, how hippocampal oscillations differentiate between successful memory retrieval within a session and consolidation across TEBC training sessions remains unknown. To address this question, we recorded local field potentials (LFPs) from the rat dorsal hippocampus during TEBC and investigated hippocampal oscillation dynamics associated with these two functions. We show that transient broadband responses to the CS were correlated with memory consolidation, as indexed by an increase in CRs across TEBC sessions. In contrast, induced alpha (8–10 Hz) and beta (16–20 Hz) band responses were correlated with the successful retrieval of the CS–US association within a session, as indexed by the difference in trials with and without CR.

AB - Trace eyeblink conditioning (TEBC) has been widely used to study associative learning in both animals and humans. In this paradigm, conditioned responses (CRs) to conditioned stimuli (CS) serve as a measure for retrieving learned associations between the CS and the unconditioned stimuli (US) within a trial. Memory consolidation, that is, learning over time, can be quantified as an increase in the proportion of CRs across training sessions. However, how hippocampal oscillations differentiate between successful memory retrieval within a session and consolidation across TEBC training sessions remains unknown. To address this question, we recorded local field potentials (LFPs) from the rat dorsal hippocampus during TEBC and investigated hippocampal oscillation dynamics associated with these two functions. We show that transient broadband responses to the CS were correlated with memory consolidation, as indexed by an increase in CRs across TEBC sessions. In contrast, induced alpha (8–10 Hz) and beta (16–20 Hz) band responses were correlated with the successful retrieval of the CS–US association within a session, as indexed by the difference in trials with and without CR.

KW - classical conditioning

KW - cross-frequency coupling

KW - hippocampus

KW - memory

KW - phase locking

U2 - 10.1523/ENEURO.0030-23.2024

DO - 10.1523/ENEURO.0030-23.2024

M3 - Journal article

C2 - 38627063

AN - SCOPUS:85191324257

VL - 11

JO - eNeuro

JF - eNeuro

SN - 2373-2822

IS - 4

M1 - ENEURO.0030-23.2024

ER -