Disability adjusted life years associated with COVID-19 in Denmark in the first year of the pandemic
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Disability adjusted life years associated with COVID-19 in Denmark in the first year of the pandemic. / Pires, Sara M.; Redondo, Hernan G.; Espenhain, Laura; Jakobsen, Lea S.; Legarth, Rebecca; Meaidi, Marianna; Koch, Anders; Tribler, Siri; Martin-Bertelsen, Tomas; Ethelberg, Steen.
I: BMC Public Health, Bind 22, Nr. 1, 1315, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Disability adjusted life years associated with COVID-19 in Denmark in the first year of the pandemic
AU - Pires, Sara M.
AU - Redondo, Hernan G.
AU - Espenhain, Laura
AU - Jakobsen, Lea S.
AU - Legarth, Rebecca
AU - Meaidi, Marianna
AU - Koch, Anders
AU - Tribler, Siri
AU - Martin-Bertelsen, Tomas
AU - Ethelberg, Steen
PY - 2022
Y1 - 2022
N2 - Background Burden of disease studies measure the public health impact of a disease in a society. The aim of this study was to quantify the direct burden of COVID-19 in the first 12 months of the epidemic in Denmark. Methods We collected national surveillance data on positive individuals for SARS-CoV-2 with RT-PCR, hospitalization data, and COVID-19 mortality reported in the period between 26(th) of February, 2020 to 25(th) of February, 2021. We calculated disability adjusted life years (DALYs) based on the European Burden of Disease Network consensus COVID-19 model, which considers mild, severe, critical health states, and premature death. We conducted sensitivity analyses for two different death-registration scenarios, within 30 and 60 days after first positive test, respectively. Results We estimated that of the 211,823 individuals who tested positive to SARS-CoV-2 by RT-PCR in the one-year period, 124,163 (59%; 95% uncertainty interval (UI) 112,782-133,857) had at least mild symptoms of disease. The total estimated disease burden was 30,180 DALYs (95% UI 30,126; 30,242), corresponding to 520 DALYs/100,000. The disease burden was higher in the age groups above 70 years of age, particularly in men. Years of life lost (YLL) contributed with more than 99% of total DALYs. The results of the scenario analysis showed that defining COVID-19-related fatalities as deaths registered up to 30 days after the first positive test led to a lower YLL estimate than when using a 60-days window. Conclusion COVID-19 led to a substantial public health impact in Denmark in the first full year of the epidemic. Our estimates suggest that it was the the sixth most frequent cause of YLL in Denmark in 2020. This impact will be higher when including the post-acute consequences of COVID-19 and indirect health outcomes.
AB - Background Burden of disease studies measure the public health impact of a disease in a society. The aim of this study was to quantify the direct burden of COVID-19 in the first 12 months of the epidemic in Denmark. Methods We collected national surveillance data on positive individuals for SARS-CoV-2 with RT-PCR, hospitalization data, and COVID-19 mortality reported in the period between 26(th) of February, 2020 to 25(th) of February, 2021. We calculated disability adjusted life years (DALYs) based on the European Burden of Disease Network consensus COVID-19 model, which considers mild, severe, critical health states, and premature death. We conducted sensitivity analyses for two different death-registration scenarios, within 30 and 60 days after first positive test, respectively. Results We estimated that of the 211,823 individuals who tested positive to SARS-CoV-2 by RT-PCR in the one-year period, 124,163 (59%; 95% uncertainty interval (UI) 112,782-133,857) had at least mild symptoms of disease. The total estimated disease burden was 30,180 DALYs (95% UI 30,126; 30,242), corresponding to 520 DALYs/100,000. The disease burden was higher in the age groups above 70 years of age, particularly in men. Years of life lost (YLL) contributed with more than 99% of total DALYs. The results of the scenario analysis showed that defining COVID-19-related fatalities as deaths registered up to 30 days after the first positive test led to a lower YLL estimate than when using a 60-days window. Conclusion COVID-19 led to a substantial public health impact in Denmark in the first full year of the epidemic. Our estimates suggest that it was the the sixth most frequent cause of YLL in Denmark in 2020. This impact will be higher when including the post-acute consequences of COVID-19 and indirect health outcomes.
KW - Burden of disease
KW - DALY
KW - YLD
KW - YLL
KW - Population health
KW - Denmark
KW - European burden of disease network
KW - Coronavirus
KW - COVID-19
KW - BURDEN
KW - DISEASE
KW - POPULATION
KW - CHILDREN
U2 - 10.1186/s12889-022-13694-9
DO - 10.1186/s12889-022-13694-9
M3 - Journal article
C2 - 35804310
VL - 22
JO - BMC Public Health
JF - BMC Public Health
SN - 1471-2458
IS - 1
M1 - 1315
ER -
ID: 314275097