Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA
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Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA. / Pinto, Vera V; Ditlev, Sisse B; Jensen, Kamilla E; Resende, Mafalda; Dahlbäck, Madeleine; Andersen, Gorm; Andersen, Pernille; Theander, Thor G; Salanti, Ali; Nielsen, Morten A.
I: P L o S One, Bind 6, Nr. 3, 01.01.2011, s. e17942.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA
AU - Pinto, Vera V
AU - Ditlev, Sisse B
AU - Jensen, Kamilla E
AU - Resende, Mafalda
AU - Dahlbäck, Madeleine
AU - Andersen, Gorm
AU - Andersen, Pernille
AU - Theander, Thor G
AU - Salanti, Ali
AU - Nielsen, Morten A
PY - 2011/1/1
Y1 - 2011/1/1
N2 - In Plasmodium falciparum malaria endemic areas placental malaria (PM) is an important complication of malaria. The recurrence of malaria in primigravidae women irrespective of acquired protection during childhood is caused by the interaction between the parasite-expressed VAR2CSA antigen and chondroitin sulfate A (CSA) in the placental intervillous space and lack of protective antibodies. PM impairs fetal development mainly by excessive inflammation processes. After infections during pregnancy women acquire immunity to PM conferred by antibodies against VAR2CSA. Ideally, a vaccine against PM will induce antibody-mediated immune responses that block the adhesion of infected erythrocytes (IE) in the placenta.
AB - In Plasmodium falciparum malaria endemic areas placental malaria (PM) is an important complication of malaria. The recurrence of malaria in primigravidae women irrespective of acquired protection during childhood is caused by the interaction between the parasite-expressed VAR2CSA antigen and chondroitin sulfate A (CSA) in the placental intervillous space and lack of protective antibodies. PM impairs fetal development mainly by excessive inflammation processes. After infections during pregnancy women acquire immunity to PM conferred by antibodies against VAR2CSA. Ideally, a vaccine against PM will induce antibody-mediated immune responses that block the adhesion of infected erythrocytes (IE) in the placenta.
KW - Animals
KW - Antibodies, Protozoan
KW - Antibody Formation
KW - Antigens, Protozoan
KW - Enzyme-Linked Immunosorbent Assay
KW - Epitopes
KW - Erythrocytes
KW - Female
KW - Humans
KW - Immunoglobulin G
KW - Malaria Vaccines
KW - Malaria, Falciparum
KW - Mice
KW - Placenta
KW - Plasmodium falciparum
KW - Pregnancy
KW - Protein Array Analysis
KW - Protein Structure, Tertiary
KW - Rabbits
KW - Rats
KW - Recombinant Proteins
KW - Species Specificity
U2 - 10.1371/journal.pone.0017942
DO - 10.1371/journal.pone.0017942
M3 - Journal article
C2 - 21464946
VL - 6
SP - e17942
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 3
ER -
ID: 35277138