Differential gene regulation in the anterior cingulate cortex and superior temporal cortex in schizophrenia: A molecular network approach
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Differential gene regulation in the anterior cingulate cortex and superior temporal cortex in schizophrenia : A molecular network approach. / Gebicke-Haerter, Peter J.; Leonardi-Essmann, Fernando; Haerter, Jan O.; Rossner, Moritz J.; Falkai, Peter; Schmitt, Andrea; Raabe, Florian J.
I: Schizophrenia Research, Bind 232, 01.06.2021, s. 1-10.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Differential gene regulation in the anterior cingulate cortex and superior temporal cortex in schizophrenia
T2 - A molecular network approach
AU - Gebicke-Haerter, Peter J.
AU - Leonardi-Essmann, Fernando
AU - Haerter, Jan O.
AU - Rossner, Moritz J.
AU - Falkai, Peter
AU - Schmitt, Andrea
AU - Raabe, Florian J.
PY - 2021/6/1
Y1 - 2021/6/1
N2 - The closely connected anterior cingulate cortex (ACC) and superior temporal cortex (STC) are important for higher cognitive functions. Both brain regions are disturbed in schizophrenia, i.e., functional and structural alterations have been reported. This postmortem investigation in brains from patients with schizophrenia and controls compared gene expression in the left ACC and left STC. Most differentially expressed genes were unique to each brain region, but some clusters of genes were equally dysregulated in both, giving rise to a more general disease-specific pattern of gene regulation. The data was used to construct a molecular network of the genes identically expressed in both regions as primary nodes and the metabolically connected genes as secondary nodes. The network analysis identified downregulated clusters of immune-associated gene products and upregulated clusters belonging to the ubiquitin-proteasome system. These findings could help to identify new potential therapeutic targets for future approaches. (c) 2021 Elsevier B.V. All rights reserved.
AB - The closely connected anterior cingulate cortex (ACC) and superior temporal cortex (STC) are important for higher cognitive functions. Both brain regions are disturbed in schizophrenia, i.e., functional and structural alterations have been reported. This postmortem investigation in brains from patients with schizophrenia and controls compared gene expression in the left ACC and left STC. Most differentially expressed genes were unique to each brain region, but some clusters of genes were equally dysregulated in both, giving rise to a more general disease-specific pattern of gene regulation. The data was used to construct a molecular network of the genes identically expressed in both regions as primary nodes and the metabolically connected genes as secondary nodes. The network analysis identified downregulated clusters of immune-associated gene products and upregulated clusters belonging to the ubiquitin-proteasome system. These findings could help to identify new potential therapeutic targets for future approaches. (c) 2021 Elsevier B.V. All rights reserved.
KW - Postmortem
KW - Schizophrenia
KW - Gene expression
KW - Anterior cingulate cortex
KW - Molecular networks
KW - PREFRONTAL CORTEX
KW - MICROGLIAL ACTIVATION
KW - BRAIN
KW - EXPRESSION
KW - PROTEIN
KW - METAANALYSIS
KW - RISK
KW - MIND
KW - RISPERIDONE
KW - UBIQUITIN
U2 - 10.1016/j.schres.2021.04.014
DO - 10.1016/j.schres.2021.04.014
M3 - Journal article
C2 - 34004381
VL - 232
SP - 1
EP - 10
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
ER -
ID: 276380389