Dietary intake of advanced glycation end products (Ages) and mortality among individuals with colorectal cancer
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Dietary intake of advanced glycation end products (Ages) and mortality among individuals with colorectal cancer. / Mao, Ziling; Aglago, Elom K.; Zhao, Zhiwei; Schalkwijk, Casper; Jiao, Li; Freisling, Heinz; Weiderpass, Elisabete; Hughes, David J.; Eriksen, Anne Kirstine; Tjønneland, Anne; Severi, Gianluca; Rothwell, Joseph; Boutron-Ruault, Marie Christine; Katzke, Verena; Kaaks, Rudolf; Schulze, Matthias B.; Birukov, Anna; Krogh, Vittorio; Panico, Salvatore; Tumino, Rosario; Ricceri, Fulvio; Bueno-De-mesquita, H. Bas; Vermeulen, Roel C.H.; Gram, Inger T.; Skeie, Guri; Sandanger, Torkjel M.; Quirós, J. Ramón; Crous-Bou, Marta; Sánchez, Maria Jose; Amiano, Pilar; Chirlaque, María Dolores; Gurrea, Aurelio Barricarte; Manjer, Jonas; Johansson, Ingegerd; Perez-Cornago, Aurora; Jenab, Mazda; Fedirko, Veronika.
I: Nutrients, Bind 13, Nr. 12, 4435, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Dietary intake of advanced glycation end products (Ages) and mortality among individuals with colorectal cancer
AU - Mao, Ziling
AU - Aglago, Elom K.
AU - Zhao, Zhiwei
AU - Schalkwijk, Casper
AU - Jiao, Li
AU - Freisling, Heinz
AU - Weiderpass, Elisabete
AU - Hughes, David J.
AU - Eriksen, Anne Kirstine
AU - Tjønneland, Anne
AU - Severi, Gianluca
AU - Rothwell, Joseph
AU - Boutron-Ruault, Marie Christine
AU - Katzke, Verena
AU - Kaaks, Rudolf
AU - Schulze, Matthias B.
AU - Birukov, Anna
AU - Krogh, Vittorio
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Ricceri, Fulvio
AU - Bueno-De-mesquita, H. Bas
AU - Vermeulen, Roel C.H.
AU - Gram, Inger T.
AU - Skeie, Guri
AU - Sandanger, Torkjel M.
AU - Quirós, J. Ramón
AU - Crous-Bou, Marta
AU - Sánchez, Maria Jose
AU - Amiano, Pilar
AU - Chirlaque, María Dolores
AU - Gurrea, Aurelio Barricarte
AU - Manjer, Jonas
AU - Johansson, Ingegerd
AU - Perez-Cornago, Aurora
AU - Jenab, Mazda
AU - Fedirko, Veronika
N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021
Y1 - 2021
N2 - Advanced glycation end-products (AGEs) may promote oxidative stress and inflammation and have been linked to multiple chronic diseases, including cancer. However, the association of AGEs with mortality after colorectal cancer (CRC) diagnosis has not been previously investigated. Multivariable Cox proportional hazards models were used to calculate hazard ratios and corresponding 95% confidence intervals for associations between dietary intake of AGEs with CRC-specific and all-cause mortality among 5801 participant cases diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition study between 1993 and 2013. Dietary intakes of AGEs were estimated using country-specific dietary questionnaires, linked to an AGE database, that accounted for food preparation and processing. During a median of 58 months of follow-up, 2421 cases died (1841 from CRC). Individually or combined, dietary intakes of AGEs were not associated with all-cause and CRC-specific mortality among cases. However, there was a suggestion for a positive association between AGEs and all-cause or CRC-specific mortality among CRC cases without type II diabetes (all-cause, Pinteraction = 0.05) and CRC cases with the longest follow-up between recruitment and cancer diagnosis (CRC-specific, Pinteraction = 0.003; all-cause, Pinteraction = 0.01). Our study suggests that pre-diagnostic dietary intakes of AGEs were not associated with CRC-specific or all-cause mortality among CRC patients. Further investigations using biomarkers of AGEs and stratifying by sex, diabetes status, and timing of exposure to AGEs are warranted.
AB - Advanced glycation end-products (AGEs) may promote oxidative stress and inflammation and have been linked to multiple chronic diseases, including cancer. However, the association of AGEs with mortality after colorectal cancer (CRC) diagnosis has not been previously investigated. Multivariable Cox proportional hazards models were used to calculate hazard ratios and corresponding 95% confidence intervals for associations between dietary intake of AGEs with CRC-specific and all-cause mortality among 5801 participant cases diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition study between 1993 and 2013. Dietary intakes of AGEs were estimated using country-specific dietary questionnaires, linked to an AGE database, that accounted for food preparation and processing. During a median of 58 months of follow-up, 2421 cases died (1841 from CRC). Individually or combined, dietary intakes of AGEs were not associated with all-cause and CRC-specific mortality among cases. However, there was a suggestion for a positive association between AGEs and all-cause or CRC-specific mortality among CRC cases without type II diabetes (all-cause, Pinteraction = 0.05) and CRC cases with the longest follow-up between recruitment and cancer diagnosis (CRC-specific, Pinteraction = 0.003; all-cause, Pinteraction = 0.01). Our study suggests that pre-diagnostic dietary intakes of AGEs were not associated with CRC-specific or all-cause mortality among CRC patients. Further investigations using biomarkers of AGEs and stratifying by sex, diabetes status, and timing of exposure to AGEs are warranted.
KW - Advanced glycation end-products
KW - All-cause mortality
KW - Colorectal cancer mortality
KW - Dietary advanced glycation end-products
U2 - 10.3390/nu13124435
DO - 10.3390/nu13124435
M3 - Journal article
C2 - 34959986
AN - SCOPUS:85120756097
VL - 13
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 12
M1 - 4435
ER -
ID: 290600912